57164-99-5

Usage

InChI:InChI=1/C8H12N2O3S/c1-13-8-5-6(9)3-4-7(8)10-14(2,11)12/h3-5,10H,9H2,1-2H3

Upstream product

• 57164-98-4 N-(2-methoxy-4-nitrophenyl)methanesulfonamide 
• 97-52-9 2-methoxy-4-nitrophenylamine 

Downstream Products

• 108792-07-0 2-methoxy-4-pivalamido-N-methanesulphonyl aniline 
• 870090-63-4 4-methoxy-3-nitro-N-(4-methanesulfonylamino-3-methoxyphenyl)benzamide 
• 870090-58-7 N-(3-methoxy-4-methanesulfonylaminophenyl)-3,4-methylenedioxybenzamide 
• 108792-15-0 N-[4-[(E)-Methanesulfonylimino]-3-methoxy-cyclohexa-2,5-dien-(E)-ylidene]-2,2-dimethyl-propionamide 

Relevant academic research and scientific papers

Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents

Previously synthesized tubulin inhibitors showed promising in vitro selectivity and activity against Human African Trypanosomiasis. Current aim is to improve the ligand efficiency and reduce overall hydrophobicity of the compounds, by lead optimization. V

SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES

Substituted diaryl compounds of the Formulae (I, II, III), where the variables are as defined in the claims, and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.

QUINONE-IMIDES : REGIOSPECIFICITY OF NUCLEOPHILIC ATTACK ON N-ALKANESULPHONYL-N'-ALKANOYL 1,4-BENZOQUINONE-IMINES.

Substrates such as (2) undergo regiospecific attack by azide and thiocyanate ions at the terminus of the C=C-C=N-CO system.In the case of addition of azide, this is proved by the detailed analysis of the 1H and 13C NMR spectra of the products (11) derived from the quinone-imides (8).The structure of the products obtained by the addition of thiocyanate to the quinone-imides (10) and (20) is proved by their facile cyclisation to the 2-aminobenzothiazoles (18) and (21) respectively.