5717-38-4

Upstream product

• 107-08-4 1-iodo-propane 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 3728-50-5 butylidenetriphenylphosphorane 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 29304-46-9 2-Hydrocinnamoyl-n-valeriansaeure-aethylester 
• 894855-52-8 ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate 
• 130556-98-8 C₃₃H₂₇F₁₅NO₂P 
• 2819-55-8 3-Oxo-6-phenyl-2-propyl-hexansaeure-aethylester 
• 5717-46-4 ethyl 4,4-diphenyl-2-propyl-2,3-butadienoate 
• 5717-49-7 α-Propyl-γ,γ-diphenyl-allencarbonsaeure 

Relevant academic research and scientific papers

Olefin-Directed Palladium-Catalyzed Regio- and Stereoselective Oxidative Arylation of Allenes

An olefin-directed palladium-catalyzed oxidative regio- and stereoselective arylation of allenes to afford 1,3,6-trienes has been established. A number of functionalized allenes, including 2,3- and 3,4-dienoates and 3,4-dienol derivatives, have been inves

Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors

The excessive calpain activation causes serious cellular damage or even cell death in neurological disorders such as stroke and Alzheimer's disease. Oxidative stress has also been implicated in the initiation or progression of neurodegenerative diseases. In the present studies, a series of cinnamoyl ketoamides 4a-4j were synthesized as hybrid structures of antioxidants and calpain inhibitors. Cinnamoyl ketoamides, possessing an alkyl chain at the α-position, showed potent μ-calpain inhibitory activities indicating that the cinnamoyl skeleton can be regarded as an acyclic variant of calpain inhibitory chromone carboxamide 2. Among synthesized, compound 4e was the most potent inhibitor of μ-calpain (IC50 = 0.13 μM) and also exhibited strong antioxidant activities in DPPH and superoxide anion radical scavenging and lipid peroxidation inhibition assay systems.

VALPROIC ACID ANALOGUES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Analogues of valproic acid useful in treating neuroaffective disorders including convulsions, bipolar disorder, and migraine headache are disclosed. The analogues are halide substituted analogues, cyclic analogues, and conjugated diene analogues of valproic acid. Pharmaceutical compositions or prodrugs containing the analogues or pharmaceutically acceptable salts thereof are disclosed. Methods of making the compounds and treating mammals with neuroaffective disorders are also disclosed.