57182-70-4

Usage

Physical state

White solid.

Odor

Distinct.

Solubility

Soluble in organic solvents.

Primary use

Rubber accelerator in the manufacturing of tires and other rubber products.

Benefits

Hastens vulcanization process, improved tensile strength, elasticity, and resistance to heat and aging in rubber materials.

Secondary use

Chemical intermediate in the production of dyes, pharmaceuticals, and other organic compounds.

Safety precautions

Handle with caution, as it is a skin and eye irritant and may cause allergic reactions in some individuals.

InChI:InChI=1/C9H11NS/c1-6-3-4-8(9(10)11)7(2)5-6/h3-5H,1-2H3,(H2,10,11)

Upstream product

• 73258-94-3 2,4-dimethyl benzamide 

Downstream Products

• 77358-41-9 2-(2,4-Dimethylphenyl)-4,5-thiazolindion 
• 57182-84-0 6-(2,4-dimethyl-phenyl)-3-isopropyl-2-phenyl-2,3-dihydro-[1,3,5]thiadiazin-4-one 
• 77358-66-8 6-(2,4-Dimethylphenyl)-2,3-dihydro-3-(2-naphthyl)-2-phenyl-4H-1,3,5-thiadiazin-4-on 
• 57182-79-3 2,4-Dimethylthiobenzoylisocyanat 
• 57182-75-9 5-(2,4-Dimethylphenyl)-1,2,4-dithiazol-3-on 

Relevant academic research and scientific papers

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.