5719-17-5

Basic information

• Product Name: 2-[(Z)-1-bromo-2-phenylethenyl]-2,3-dihydro-1H-perimidine
• CAS NO: 5719-17-5
• Molecular Formula: C₁₉H₁₅BrN₂
• Molecular Weight: 351.2398
• Mol File: 5719-17-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 558.2°C at 760 mmHg
• Flash Point: 291.4°C
• Density: 1.438g/cm³
• Vapor Pressure: 1.71E-12mmHg at 25°C
• Refractive Index: 1.722
• CAS DataBase Reference: 2-[(Z)-1-bromo-2-phenylethenyl]-2,3-dihydro-1H-perimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Z)-1-bromo-2-phenylethenyl]-2,3-dihydro-1H-perimidine(5719-17-5)
• EPA Substance Registry System: 2-[(Z)-1-bromo-2-phenylethenyl]-2,3-dihydro-1H-perimidine(5719-17-5)

Safety Data

• Hazardous Substances Data: 5719-17-5(Hazardous Substances Data)

Relevant articles and documents

Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds

PCT No. PCT/EP96/05766 Sec. 371 Date Aug. 26, 1998 Sec. 102(e) Date Aug. 26, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23465 PCT Pub. Date Jul. 3, 1997Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal monocycle for moieties (c)-(d) is unsubstituted or substituted by a substituent selected from the group consisting of -NH2, -NO2, -SO2NH2, -SO2CH3, acetyl, hydroxy, methoxy, ethoxy, cyano and halogen; R2 and R3 are each hydrogen; and R4 and R5, together with the nitrogen atom to which they are bound, form a piperazinyl or piperidyl ring, wherein the piperazinyl ring is substituted in the 4-position with a substituent selected from the group consisting of (a) a 6-membered aromatic monocycle having 0, 1 or 2 nitrogen atoms and the remainder of the atoms in the monocycle being carbon and (b) hydroxy-C1-C6 alkyl, wherein the monocycle is unsubstituted or substituted by a substituent selected from the group consisting of halogen, -NH2, -NO2, -SO2NH2, -SO2CH3, acetyl and cyano.