57192-07-1

Upstream product

• 768-70-7 1-ethynyl-3-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 591-31-1 3-methoxy-benzaldehyde 
• 253684-23-0 1,1-dibromo-2-(3-methoxyphenyl)ethene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 27913-19-5 3-(3-methoxyphenyl)prop-2-yn-1-ol 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 639850-07-0 N-[3-(3-methoxyphenyl)prop-2-ynylidene]-P,P-diphenylphosphinamide 
• 1609683-09-1 C₁₁H₉NO₂ 
• 1609683-15-9 C₁₇H₂₃NO₂Si 
• 1609683-21-7 C₂₃H₃₁NO₂Si 
• 1609683-29-5 C₂₃H₃₁NO₂Si 
• 1609683-22-8 C₂₃H₃₀FNO₂Si 
• 1609683-30-8 C₂₃H₃₀FNO₂Si 
• 1609683-23-9 C₂₃H₃₀ClNO₂Si 
• 1609683-31-9 C₂₃H₃₀ClNO₂Si 
• 1609683-37-5 C₂₈H₃₉NO₄Si 
• 1609683-53-5 C₂₂H₂₅NO₄ 

Relevant academic research and scientific papers

Combining silver- and organocatalysis: An enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee).

Combining silver catalysis and organocatalysis: A sequential michael addition/hydroalkoxylation one-pot approach to annulated coumarins

A highly stereoselective one-pot procedure for the synthesis of five-membered annulated hydroxycoumarins has been developed. By merging primary amine catalysis with silver catalysis, a series of functionalized coumarin derivatives were obtained in good yields (up to 91%) and good to excellent enantioselectivities (up to 99% ee) via a Michael addition/hydroalkoxylation reaction. Depending on the substituents on the enynone, the synthesis of annulated six-membered rings is also feasible.

Enzyme and Gold Catalysis: A New Enantioselective Entry into Functionalized 4-Hydroxy-2-pyrrolines

A new route toward functionalized pyrrolines starting from acetylenic aldehydes was developed. Key steps involved a ?hydroxynitrile lyase catalyzed asymmetric hydrocyanation of acetylenic aldehydes and a gold-catalyzed cyclization of substituted acetylene-containing amino alcohols. Georg Thieme Verlag Stuttgart, New York.

Zinc-catalyzed [4+3] cycloaddition with concomitant furan annulation: Formation of cyclohepta[b]furans

A convenient zinc-promoted [4+3] cycloaddition of a carbonyl ene-yne with simple dienes was first achieved. This reaction provided an efficient strategy to prepare various cyclohepta[b]furan rings by cascade cycloadditions. Additionally, a multicomponent reaction of dione, alkynal, and diene was also reported, which exhibited a novel strategy for selective creations of C-O bonds and C-C bonds. Go tandem! A first zinc-catalyzed tandem [4+3] cycloaddition is presented herein. Various substituted cyclohepta[b]furans were synthesized from carbonyl ene-yne and diene in moderate to good yield. Furan rings and seven-membered rings were prepared in one single step (see scheme; TBS=tert-butyldimethyl).

3,5-Disubstituted 6H-pyrrolo[1,2-c][1,2,3]triazoles from Morita-Baylis-Hillman adducts of propargyl aldehydes

A simple method for synthesizing several 6H-pyrrolo[1,2-c][1,2,3]triazole derivatives having a methoxycarbonyl or an acetyl group at C-5 position and 7,8-dihydro-4H-[1,2,3]triazolo[1,5-a]indol-5(6H)-ones via an intramolecular 1,3-dipolar cycloaddition reaction of azido enynes, which were readily obtained from the Morita-Baylis-Hillman acetates of propargyl aldehydes with sodium azide, has been developed.

SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF

The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.