57198-53-5Relevant articles and documents
Inhibition of serine proteases: Activity of 1,3-diazetidine-2,4-diones
Aoyama, Yasunori,Uenaka, Masaaki,Konoike, Toshiro,Hayasaki-Kajiwara, Yoko,Naya, Noriyuki,Nakajima, Masatoshi
, p. 1691 - 1694 (2007/10/03)
The present work demonstrates that the 1,3-diazetidine-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and α-chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase.