57221-67-7

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 93-08-3 methyl 2-naphthyl ketone 
• 6099-04-3 3-methoxycinnamic acid 
• 14289-45-3 2-(naphthalen-2-yl)-2-oxoacetic acid 

Downstream Products

• 1465270-10-3 C₂₃H₁₈O 
• 1465270-27-2 C₃₀H₂₄O₃S 

Relevant academic research and scientific papers

Chalcones: As potent α-amylase enzyme inhibitors; synthesis, in vitro, and in silico studies

Background: The inhibition of α-amylase enzyme is one of the best therapeutic approach for the management of type II diabetes mellitus. Chalcone possesses a wide range of biological activities. Objective: In the current study chalcone derivatives (1-16) w

Silver-catalyzed double-decarboxylative cross-coupling of α-keto acids with cinnamic acids in water: A strategy for the preparation of chalcones

A silver-catalyzed double-decarboxylative protocol has been proposed for the construction of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids under the mild aqueous conditions. The developed method for constructing C-C bonds via double-decarboxylative reactions is efficient, practical, and environmentally benign by using the readily available starting materials. It should provide a promising synthesis candidate for the formation of diverse and useful chalcone derivatives in the fields of synthetic and pharmaceutical chemistry.

One-pot synthesis of multifunctionalized m-terphenyls

A facile one-step synthetic protocol toward multifunctionalized m-terphenyls 5 and sulfonyl m-terphenyls 6 is developed from substituted chalcones 1 and allyl sulfone 2 in good yields via a [3C+3C] annulation. The NaH-mediated annulation features transition metal catalyst-free condition. Chalcones 1 with the functional groups tolerance are easily prepared via Claisen-Schmidt condensation of substituted benzaldehydes 3 with acetophenone 4 in a qualitative yield under an aqueous alkaline methanolic solution.

Antimicrobial activities of some novel synthesized aryl-pyrazole, isoxazole, pyran and pyridine derivatives from 3-ARYL-1-(2-naphthyl) prop-2-en-1-ones

3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with.......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5-diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.

Antimicrobial activities of some novel synthesized aryl-pyrazole, isoxazole, pyran and pyridine derivatives from 3-aryl-l-(2-naphthyl) prop-2-en-l-ones

3-ARYL-1 -(2-naphthy l)prop-2-en-1 -ones (1) were reacted with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.