57221-80-4

Upstream product

• 51326-52-4 8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol 
• 629-41-4 1,8-Octanediol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 101972-90-1 8-nitrooctan-1-ol 

Downstream Products

• 112487-81-7 9-benzenesulfonyl-1-(tetrahydro-2H-pyran-2-yl)oxy-7-nonene 
• 112464-08-1 1,1-bisbenzenesulfonyl 9-<(tetrahydro-2H-pyran-2-yl)oxy> 2-nonene 
• 42513-42-8 E₈,E₁₀-dodecadien-1-ol 
• 35148-18-6 (Z)-9-dodecenol 
• 98398-50-6 (Z)-1-(2-tetrahydropyranyloxy)dodec-8-ene 
• 64604-69-9 1-(2-tetrahydropyranyloxy)dodec-8(E)-ene 
• 96249-88-6 8-Acetoxy-9-phenylsulphinyl-1-tetrahydropyranyloxydodec-10(E)-ene 
• 1026888-20-9 2-((8Z,11Z,13E)-(S)-15-Benzyloxy-icosa-8,11,13-trienyloxy)-tetrahydro-pyran 
• 33956-49-9 (8E,10E)-dodeca-8,10-dienol 
• 139269-65-1 Toluene-4-sulfonic acid (Z)-tridec-8-enyl ester 
• 54699-43-3 8-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-octanoic acid 
• 139269-62-8 2-((E)-9-Benzenesulfonyl-tridec-8-enyloxy)-tetrahydro-pyran 
• 66410-28-4 trans-2,cis-13-octadecadien-1-ol 
• 53120-26-6 (3E, 13Z)-3,13-octadecadien-1-yl acetate 

Relevant academic research and scientific papers

Synthesis of a highly fluorinated fatty acid analog

A five-step synthesis of Z-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18- heptadecafluoro-octadec-8-enoic acid is reported, starting from 1,8-octanediol and 1,1,2,2,3,3,4,4.5,5,6,6,7,7,8,8-heptadecafluoro-10-iododecane. The key step is a Wittig react

IDEBENONE COMPOUNDS

The present application provides idebenone derivatives or analogues useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating the disease or disorder are also provided.

Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies

Guineensine ((2E,4E,12E)-13-(benzo[d][1,3]dioxol-5-yl)-N-isobutyltrideca-2,4,12-trienamide) is a plant-derived natural product that inhibits reuptake of the endocannabinoid anandamide with sub-micromolar potency. We have established a highly efficient tot

DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR

The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents -CHO, -C(=O)R5, -COOR5 (wherein R5 represents a C1-7 alkyl group), -CH2OH or -COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

Total synthesis of patulolide C and 11-epipatulolide C

The total synthesis of 12-membered macrolides, patulolide C, 11-epipatulolide C and formal synthesis of patulolide A and epipatulolide A, starting from 1,8-octane diol is reported. A combination of Jacobsen's hydrolytic kinetic resolution and Sharpless epoxidation is used for the creation of two stereogenic centres, while ring-closing metathesis strategy was used for the construction of the lactone ring.

Synthesis of medium- and large-sized lactones in an aqueous-organic biphasic system

(Chemical Equation Presented) Saving solvent: An aqueous-ethyl acetate biphasic system allows an efficient synthesis of medium- and large-sized lactones by an intramolecular Tsuji-Trost reaction (see scheme, n = 1-5). The macrocyclization protocol does not require a large quantity of solvents or a slow-addition technique.

Synthesis and characterization of hexadecadienyl compounds with a conjugated diene system, sex pheromone of the persimmon fruit moth and related compounds

Hexadecadien-1-ol and the derivatives (acetate and aldehyde) with a conjugated diene system have recently been identified from a pheromone gland extract of the persimmon fruit moth (Stathmopoda masinissa), a pest insect of persimmon fruits distributed in

Asymmetric synthesis of unnatural (Z,Z,E)-octadecatrienoid and eicosatrienoid by lipoxygenase-catalyzed oxygenation

The asymmetric synthesis of unnatural 13-hydroxy-(6Z,9Z,11E,13S)-octadecatrienoid and 15-hydroxy-(8Z,11Z,13E,15S)-eicosatrienoid is described using a biomimetic oxidation route. The main highlights of this synthesis are the asymmetric hydroxylation of the substrate with soybean lipoxygenase and cis selective Wittig olefination.

Stereoselective synthesis of cyclic ethers by intramolecular trapping of dicobalt hexacarbonyl-stabilized propargylic cations

The intramolecular attack of a hydroxy group on an exo-biscobalthexacarbonyl propargylic cation provides cyclic ethers with six- to nine-membered rings. The scope and limitations of the methodology are described. The reaction is stereoselective when addit