57233-20-2Relevant academic research and scientific papers
Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets
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Page/Page column 8, (2008/06/13)
Novel peripheral antinociceptive compounds are disclosed having a pharmacophore unit that target small-diameter nerve fibers that transmit signals of pain and discomfort from the soma and viscera. By acting on this target, the pharmacophore unit obtunds pain and diminishes hyper-reflexia from organs such as the skin, the respiratory tract, the corpus, the lower urinary tract, and the bowel. The pharmacophore unit is coupled to substituents that facilitate delivery of the pharmacophore to its target.
Substituted p-menthanes
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, (2008/06/13)
Compounds are disclosed having a physiological cooling action on the skin. The compositions contain, as the effective ingredient, certain esters of p-menthane 3-carboxylic acid.
