57248-14-3

Basic information

• Product Name: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE
• Synonyms: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE;2,5-DICHLOROTHIOPHENE-3-CARBOXYLICHLORIDE
• CAS NO: 57248-14-3
• Molecular Formula: C₅HCl₃OS
• Molecular Weight: 215.48
• Mol File: 57248-14-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 125°C 15mm
• Flash Point: 101.5°C
• Appearance: /
• Density: 1.667g/cm³
• Vapor Pressure: 0.0306mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(57248-14-3)
• EPA Substance Registry System: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(57248-14-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 57248-14-3(Hazardous Substances Data)

Usage

Uses

2,5-Dichlorothiophene-3-carbonyl chloride is used as a reactant in the preparation of insecticidal hydrazine derivatives.

InChI:InChI=1/C5HCl3OS/c6-3-1-2(4(7)9)5(8)10-3/h1H

Upstream product

• 36157-41-2 2,5-dichlorothiophene-3-carboxylic acid 

Downstream Products

• 1246249-59-1 2-{4-[4-(2,5-dichlorothiophene-3-carbonyl)piperazin-1-yl]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one 
• 1418130-85-4 2,5-dichloro-N-(2-hydroxy-4-methyl-phenyl)thiophene-3-carboxamide 
• 334918-28-4 (2,5-dichloro-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanone 
• 334918-23-9 (2,5-dichloro-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanol 
• 98215-53-3 2,5-Dichloro-thiophene-3-carboxylic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide 

Relevant articles and documents

Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer

Over the past few decades, an increasing variety of molecular chaperones have been investigated for their role in tumorigenesis and as potential chemotherapeutic targets; however, the 60 kDa Heat Shock Protein (HSP60), along with its HSP10 co-chaperone, have received little attention in this regard. In the present study, we investigated two series of our previously developed inhibitors of the bacterial homolog of HSP60/10, called GroEL/ES, for their selective cytotoxicity to cancerous over non-cancerous colorectal cells. We further developed a third “hybrid” series of analogs to identify new candidates with superior properties than the two parent scaffolds. Using a series of well-established HSP60/10 biochemical screens and cell-viability assays, we identified 24 inhibitors (14%) that exhibited > 3-fold selectivity for targeting colorectal cancer over non-cancerous cells. Notably, cell viability EC50 results correlated with the relative expression of HSP60 in the mitochondria, suggesting a potential for this HSP60-targeting chemotherapeutic strategy as emerging evidence indicates that HSP60 is up-regulated in colorectal cancer tumors. Further examination of five lead candidates indicated their ability to inhibit the clonogenicity and migration of colorectal cancer cells. These promising results are the most thorough analysis and first reported instance of HSP60/10 inhibitors being able to selectively target colorectal cancer cells and highlight the potential of the HSP60/10 chaperonin system as a viable chemotherapeutic target.

(THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

A dual H1 inverse agonist/5-HT2A receptor antagonist of the formula: [Formula I], its uses, and methods for its preparation are described.

Facile synthesis of 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4- ones

Interaction between 2,5-dichlorothiophene-3-carbonyl isothiocyanate, accessible via 2,5-dichlorothiophene-3-carbonyl chloride, and model heterocyclic amines produced the respective 2,5-dichloro-N-(substituted aminocarbonothioyl) thiophene-3-carboxamides. Upon heating, the deprotonated form of the latter underwent intramolecular cyclization to deliver the corresponding 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones. The structures of these new bicyclic derivatives and their acyclic precursors are based on microanalytical and spectral (IR, MS, and NMR) data.