5727-80-0Relevant academic research and scientific papers
The selective C-mono-and C,C-dialkylation of thiophosphorylacetonitriles and reactivity of the products
Vinogradova, Natalya M.,Odinets, Irene L.,Artyushin, Oleg I.,Lyssenko, Konstantin A.,Petrovsky, Pavel V.,Mastryukova, Tatyana A.
, p. 589 - 592 (2007/10/03)
The facile synthetic route to selective C-mono-and C,C-dialkylation of thiophosphorylacetonitriles by primary haloalkanes under phase transfer catalysis conditions has been developed. Using under the same conditions unsymmetric α,ω-dihaloalkanes results i
Selective C-mono- and C, C-dialkylation of thiophosphorylacetonitriles
Odinets,Vinogradova,Artyushin,Kalyanova,Lyssenko,Petrovskii,Mastryukova,Kabachnik
, p. 960 - 966 (2007/10/03)
Alkylation of thiophosphorylacetonitriles under phase transfer catalysis conditions in the 50% NaOH/CH2Cl2 system proceeds as monoalkylation, whereas alkylation in MeCN with the use of solid KOH as a base gives a disubstituted product. The order in which the reagents were added as well as dilution of the reaction mixture affected substantially the yields of the target compounds. X-ray diffraction analysis of a single crystal of dibutyl(diphenylthiopliosphoryl)acetonitrile was carried out.
