57281-71-7Relevant academic research and scientific papers
Direct modification of tripeptides using photoinduced decarboxylative radical reactions
Maeda, Kousuke,Saito, Hikaru,Osaka, Kazuyuki,Nishikawa, Keisuke,Sugie, Mai,Morita, Toshio,Takahashi, Ichiro,Yoshimi, Yasuharu
, p. 1117 - 1123 (2015)
In order to explore the applicability of photoinduced electron transfer (PET) promoted decarboxylative reactions to the direct modification of peptides, a study was performed to assess the influence of amino acid side chains on photoreactions of N-terminal protected tripeptides. Photoinduced decarboxylation reactions of tripeptides, which are composed of central amino acids that possess alkyl, phenyl, thioether, hydroxy, and amide containing side chains, in the presence or absence of acrylonitrile and a thiol were found to proceed smoothly to give the corresponding radical addition, H-abstraction, and substitution products. Although photoreactions of tripeptides containing central amino acids with phenol and indole (Tyr and Trp) moieties do not take place efficiently, appropriate protection of these groups enables the substrates to undergo smooth photoinduced decarboxylative reactions.
How useful is ferrocene as a scaffold for the design of β-sheet foldamers?
Chowdhury, Somenath,Schatte, Gabriele,Kraatz, Heinz-Bernhard
supporting information; experimental part, p. 7056 - 7059 (2009/04/07)
(Chemical Equation Presented) Crease crossing peptide embossing: The first tripeptide ferrocene foldamers to adopt an extended β-sheet-like structure in solution and solid state are presented. The flexibility of peptide substituents in 1,n′-ferrocene-bispeptide conjugates was thought to prevent the formation of extended β-sheet foldamers. The results suggest that ferrocene is a valuable scaffold for extended β-sheets.
