5729-22-6

Basic information

• Product Name: ethyl 2,3-dibromo-3-(3,4,5-trimethoxyphenyl)propionate
• Synonyms: ethyl 2,3-dibromo-3-(3,4,5-trimethoxyphenyl)propionate
• CAS NO: 5729-22-6
• Molecular Weight: 426.102
• Mol File: 5729-22-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2,3-dibromo-3-(3,4,5-trimethoxyphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,3-dibromo-3-(3,4,5-trimethoxyphenyl)propionate(5729-22-6)
• EPA Substance Registry System: ethyl 2,3-dibromo-3-(3,4,5-trimethoxyphenyl)propionate(5729-22-6)

Safety Data

• Hazardous Substances Data: 5729-22-6(Hazardous Substances Data)

Upstream product

• 90-50-6 3,4,5-trimethoxycinnamic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1878-29-1 3,4,5-trimethoxycinnamic acid ethyl ester 
• 1878-29-1 ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate 

Downstream Products

• 123251-29-6 3-methoxy-4,5-methylenedioxycinnamyl 3',4',5'-trimethoxyphenylpropiolate 
• 4698-21-9 3-(3,4,5-trimethoxyphenyl)propiolic acid 

Relevant articles and documents

Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents

Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted 4-arylcoumarin derivatives were synthesised, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity, MAO inhibitory activity, and antioxidant activity. Most of the compounds were found to exhibit high inhibitory activity, and individual compounds have extremely excellent activities. Therefore 4-arylcoumarins provides an idea for drugs design for the development of therapeutic or preventive agents for AD.

Studies on the Constituents of the Seeds of Hernandia ovigera L. VII. Syntheses of (+/-)-Hernolactone and (+/-)-Hernandin

Two new lignans, hernolactone (1) and hernandin (2), isolated from the seeds of Hernandia ovigera L. were synthesized in racemic forms.Firstly, (+/-)-1 was obtained by utilizing the conjugate addition reaction of 4 with butenolide followed by alkylation with trimethoxybenzyl bromide and subsequent removal of the protecting groups.Synthesis of 2 was pursued using the corresponding 4-phenyl-1,2-dihydronaphthalene lactone (18).The cleavage of the lactone moiety of 18 afforded an unsaturated hydroxy acid (22).Subsequent hydrogenation of 22 followed by acidification with concentrated hydrochloric acid gave isopicrohernandin (21), leaving the 2,3-trans, 3,4-cis hydroxy acid (23), which was lactonized by means of N,N-dicyclohexylcarbodiimide to afford (+/-)-2.Keywords: Hernandia ovigera; hernolactone; hernandin; lignan; dibenzylbutyrolactone lignan; phenyltetralin lignan; isopicrohernandin; Diels-Alder reaction