572914-85-3Relevant articles and documents
A triphenylamine-based colorimetric and fluorescent probe with donor-bridge-acceptor structure for detection of G-quadruplex DNA
Wang, Ming-Qi,Zhu, Wen-Xiang,Song, Zhuan-Zhuan,Li, Shuo,Zhang, Yong-Zhao
, p. 5672 - 5676 (2015)
In this Letter, three triphenylamine-based dyes (TPA-1, TPA-2a and TPA-2b) with donor-bridge-acceptor (D-π-A) structure were designed and synthesized for the purpose of G-quadruplexes recognition. In aqueous conditions, the interactions of the dyes with G-quadruplexes were studied with the aim to establish the influence of the geometry of the dyes on their binding and probing properties. Results indicate that TPA-2b displays significant selective colorimetric and fluorescent changes upon binding of G-quadruplex DNA. More importantly, its distinct color change enables visual detection and differentiation of G-quadruplexes from single and duplex DNA structures. CD titration date reveals that TPA-2b could induce and stabilize the formation of G-quadruplex structure. All these remarkable properties of TPA-2b suggest that it should have promising application in the field of G-quadruplexes research.
Synthesis and properties of molecular switches based on the opening and closing of oxazine rings
Deniz, Erhan,Cusido, Janet,Swaminathan, Subramani,Battal, Mutlu,Impellizzeri, Stefania,Sortino, Salvatore,Raymo, Fran?isco M.
experimental part, p. 20 - 28 (2012/04/17)
We designed and synthesized a family of molecular switches each pairing an oxazine ring to a chromophoric fragment. Under the influence of either chemical or optical stimulations, the oxazine ring opens to bring the chromophoric appendage in conjugation w
