572923-34-3Relevant academic research and scientific papers
Cu-catalyzed N-arylation of oxazolidinones: An efficient synthesis of the κ-opioid receptor agonist CJ-15161
Ghosh, Arun,Sieser, Janice E.,Caron, Stephane,Couturier, Michel,Dupont-Gaudet, Kristina,Girardin, Melina
, p. 1258 - 1261 (2006)
An efficient method for intermolecular N-arylation of oxazolidinones using catalytic copper in the presence of a bidentate ligand is reported. The conditions allow the use of copper and can be used to prepare enantiopure N-aryl β-amino alcohols. A short,
Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates
Mahy, William,Plucinski, Pawel K.,Frost, Christopher G.
supporting information, p. 5020 - 5023 (2015/01/08)
An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.
