57294-96-9 Usage
Type of compound
Thiourea derivative
Uses
Pesticide and herbicide (inhibits plant growth by interfering with enzyme activity), intermediate in the synthesis of organic compounds
Appearance
White to off-white crystalline
Solubility
Sparingly soluble in water
Safety precautions
Handle and store with care, potential to cause irritation to skin, eyes, and respiratory system
Environmental and health risks
Potential risks, should be used in accordance with safety regulations and guidelines
Check Digit Verification of cas no
The CAS Registry Mumber 57294-96-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,9 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57294-96:
(7*5)+(6*7)+(5*2)+(4*9)+(3*4)+(2*9)+(1*6)=159
159 % 10 = 9
So 57294-96-9 is a valid CAS Registry Number.
57294-96-9Relevant academic research and scientific papers
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
Lin, Songnian,Lombardo, Matthew,Malkani, Sunita,Hale, Jeffrey J.,Mills, Sander G.,Chapman, Kevin,Thompson, James E.,Zhang, Wen Xiao,Wang, Ruixiu,Cubbon, Rose M.,O'Neill, Edward A.,Luell, Silvi,Carballo-Jane, Ester,Yang, Lihu
scheme or table, p. 3238 - 3242 (2010/05/02)
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.
