57294-96-9 Usage
General Description
1-(3-chlorobenzyl)-3-phenylthiourea is a chemical compound with the molecular formula C14H12ClNS. It is a thiourea derivative and is often used as a pesticide and herbicide due to its ability to inhibit plant growth by interfering with enzyme activity. It is also used as an intermediate in the synthesis of organic compounds. The compound has a white to off-white crystalline appearance and is sparingly soluble in water. It should be handled and stored with care due to its potential to cause irritation to the skin, eyes, and respiratory system. Additionally, 1-(3-chlorobenzyl)-3-phenylthiourea may have potential environmental and health risks and should be used in accordance with safety regulations and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 57294-96-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,9 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57294-96:
(7*5)+(6*7)+(5*2)+(4*9)+(3*4)+(2*9)+(1*6)=159
159 % 10 = 9
So 57294-96-9 is a valid CAS Registry Number.
57294-96-9Relevant articles and documents
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
Lin, Songnian,Lombardo, Matthew,Malkani, Sunita,Hale, Jeffrey J.,Mills, Sander G.,Chapman, Kevin,Thompson, James E.,Zhang, Wen Xiao,Wang, Ruixiu,Cubbon, Rose M.,O'Neill, Edward A.,Luell, Silvi,Carballo-Jane, Ester,Yang, Lihu
scheme or table, p. 3238 - 3242 (2010/05/02)
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.
