573-04-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-1-naphthoic acid is used as a building block for the synthesis of complex molecules in the pharmaceutical industry. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Fluoro-1-naphthoic acid is utilized for the production of various agrochemicals, contributing to the development of effective and innovative solutions for agricultural challenges.
Used in Organic Synthesis:
5-Fluoro-1-naphthoic acid serves as a reagent in organic synthesis, where it is used to introduce the 5-fluoro-1-naphthoic acid moiety into different compounds for further functionalization. This enhances the versatility and applicability of synthesized compounds in various fields.
Used in Disease Treatment Research:
5-Fluoro-1-naphthoic acid has been studied for its potential in the treatment of various diseases due to its anti-inflammatory and anti-tumor properties. Its unique chemical structure offers opportunities for the development of novel therapeutic agents targeting specific medical conditions.

InChI:InChI=1/C11H7FO2/c12-10-6-2-3-7-8(10)4-1-5-9(7)11(13)14/h1-6H,(H,13,14)

Upstream product

• 444913-40-0 ethyl 5-fluoro-1-naphthoate 
• 129158-96-9 5-bromo-1-naphthalenecarboxylic acid 1,1-dimethylethyl ester 
• 16726-67-3 5-bromo-1-naphthalenecarboxylic acid 
• 86-55-5 1-naphthalenecarboxylic acid 
• 405196-38-5 5-fluoro-1-naphthalenecarboxylic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

AMINOETHANOL DERIVATIVES

The present invention provides a pharmaceutical agent having cholesteryl ester transfer protein inhibitory action and useful as a blood lipid lowering agent and the like. The present invention relates to a compound represented by the formula wherein Ar1 is an aromatic ring group optionally having substituents, Ar2 is an aromatic ring group having substituents, OR'' is an optionally protected hydroxyl group, R is an acyl group, R' is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof, and a pharmaceutical composition containing a compound of the formula (I) or a salt thereof or a prodrug thereof.

Synthesis of mono- and difluoronaphthoic acids

Aryl carboxamides are useful structural units found in several biologically active compounds. Unlike their benzoic acid counterparts, fluorinated versions of naphthoic acids are relatively unknown. In connection with a recent project, we needed viable syntheses of several mono- and difluorinated naphthoic acids. Herein we describe the synthesis of 5-, 6-, 7-, and 8-fluoro-1-naphthalenecarboxylic acids and 5,7-, 5,8-, 6,7-, and 4,5-difluoro-1-naphthalenecarboxylic acids. The 5-fluoro derivative 1 was obtained from the corresponding 5-bromo compound via electrophilic fluorination of the lithio-intermediate. The rest of the monofluoro (2, 3, and 4) and the difluoro acids (5, 6, and 7) were prepared by a new, general route which entailed the elaboration of commercial fluorinated phenylacetic acids to 2-(fluoroaryl)glutaric acids with differential ester groups; selective hydrolysis to a mono acid, intramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures. An alternative process to assemble a naphthalene skeleton is also presented for the difluoro acids 5 and 6. Finally, 4,5-difluoro-1-naphthalenecarboxylic acid (8) was prepared expeditiously from 1,8-diaminonaphthalene by adapting classical reactions.