573-14-8Relevant academic research and scientific papers
Design, synthesis, and evaluation of efflux substrate-metal chelator conjugates as potential antimicrobial agents
Zhang, Yanling,Eric Ballard,Zheng, Shi-Long,Gao, Xingming,Ko, Ko-Chun,Yang, Hsiuchin,Brandt, Gary,Lou, Xinhui,Tai, Phang C.,Lu, Chung-Dar,Wang, Binghe
, p. 707 - 711 (2008/09/21)
Maintaining a proper balance of metal concentrations is critical to the survival of bacteria. We have designed and synthesized a series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to a
Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C
Brufani,Cesta,Filocamo,Lappa,Marta,Pomponi,Meroni,Pagella
, p. 585 - 597 (2007/10/02)
In order to study the structure-activity relationships of phenothiazine derivatives inhibiting phosphatidylinositol-specific phospholipase C (PI-PLC), the synthesis of some phenothiazine amide, amine and ester derivatives was performed mainly by reacting 10H-phenothiazine-10-propanoyl chloride with some amines and alcohols; the resulting amides were reduced with borane to yield the corresponding amines. Starting from 2-chloro and 2-trifuoromethyl-10H-phenothiazine-10-propanoyl chloride two amides were synthesized. The inhibiting activity on PI-PLC from human platelets is reported.
