573-72-8Relevant academic research and scientific papers
Synthesis of new 3-(4-fluoronaphthyl)-5-(aryl)-2-isoxazolines and their antimicrobial and spermicidal activity
Sharma, Sharda,Pathak, Late V. N.,Madan, Harsha,Sharma, Arvind
scheme or table, p. 337 - 340 (2011/12/22)
Microwave assisted synthesis of 3-(4-fluoronaphthyl)-5-(aryl)-2- isoxazolines (3) from corresponding chalcones (2) and hydroxylamine hydrochloride has been accomplished. Structures of synthesized compounds have been confirmed on the basis of spectral studies (IR, 1H NMR) and analytical data. Representative compounds have been screened for their spermicidal activity in HF cattle and were also evaluated for their antibacterial activity against Staphylococcus aureus, E coli, Pseudomonas and antifungal activity against Candida albicans, Asperigillus niger, Fusarium oxysporum.
Solvent free synthesis of new-1-acetyl-3-(4-fluoronaphthyl)-5-substituted aryl pyrazolines as spermicides
Sharma, Sharda,Sharma, Arvind
scheme or table, p. 750 - 753 (2009/12/07)
In this paper we wish to report the solvent free synthesis of 1-acetyl-3-(4-fluoronaphthyl)-5-substituted aryl pyrazolines by using simple and efficient Green Chemistry techniques (Grindstone method and microwave irradiation). These methods have been developed for the rapid solvent free synthesis of title compounds from corresponding chalcones and hydrazine hydrate or phenylhydrazine in acetic acid. Considerable increase in the reaction rates have been observed with better yields compared with sample prepared from conventional method. Structure of synthesized new compounds have been confirmed on the basis of spectral (IR, 1H NMR) and analytical data. Representative compounds have been screened for their spermicidal activity in HF catties and Murrah buffalo.
