57320-63-5 Usage
Uses
Used in Pharmaceutical Industry:
4-(Difluoromethoxy)benzoyl chloride serves as a key reagent for the synthesis of new drugs, capitalizing on its ability to introduce the difluoromethoxy group into organic molecules. This group is known to enhance the pharmacological properties of drug candidates, such as improving their metabolic stability and bioavailability.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Difluoromethoxy)benzoyl chloride is utilized as a building block for the development of novel agricultural chemicals. The incorporation of the difluoromethoxy group can lead to the creation of more effective and environmentally friendly pesticides and herbicides.
Used in Medicinal Chemistry:
4-(Difluoromethoxy)benzoyl chloride is employed as an intermediate in the synthesis of fluorinated organic compounds, which are of significant interest in medicinal chemistry. The presence of fluorine atoms can significantly alter the reactivity and binding properties of these compounds, making them valuable for the design of innovative therapeutic agents.
Used in Materials Science:
4-(Difluoromethoxy)benzoyl chloride also finds application in materials science, where fluorinated organic compounds are explored for their unique physical and chemical properties. These properties can be harnessed in the development of advanced materials with applications in various fields, such as electronics, coatings, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 57320-63-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,2 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57320-63:
(7*5)+(6*7)+(5*3)+(4*2)+(3*0)+(2*6)+(1*3)=115
115 % 10 = 5
So 57320-63-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClF2O2/c9-7(12)5-1-3-6(4-2-5)13-8(10)11/h1-4,8H
57320-63-5Relevant academic research and scientific papers
A preparation method of roflumilast
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Paragraph 0102-0103; 0108-0109; 0114-0115; 0120-0121, (2019/04/13)
The invention discloses a method for preparation of roflumilast, comprises the following steps: 4 - (methoxy) benzoic acid chlorization reaction to obtain 4 - (methoxy) benzoyl chloride; with 3, 5 - dichloro - 4 - aminopyridine by amidation reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) benzamide; then by Vismeier reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) - 3 - formyl-benzoyl; through the Baeyer - villiger - hydrolysis reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) - 3 - hydroxy benzoyl; then with the [...] yl cyclopropane ether to obtain roflumilast. The invention starting raw material is cheap, the reaction conditions are mild and controllable, synthetic route green environmental protection, high yield, the prepared Roflumilast purity is good.
RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND
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Paragraph 0524; 0525, (2015/02/25)
[Problem] Provision of a superior rhodium catalyst and a production method of amine compound. [Solving Means] A rhodium complex coordinated with a compound represented by the formula
NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 33, (2015/04/22)
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
