57339-90-9Relevant articles and documents
Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities
Jang, Soyong,Jung, Jae-Chul,Oh, Seikwan
, p. 4098 - 4105 (2007)
A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18-22 and 25-26 are described. The key synthetic strategies involve Grignard reaction of aldehyde 2 and oxidation reaction of 8-12 in high yields. The prepared compounds 18-22 an
Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents
Patel, Kuldeep,Karthikeyan, Chandrabose,Hari Narayana Moorthy, N. S.,Deora, Girdhar Singh,Trivedi, Piyush,Solomon, Viswas Raja,Lee, Hoyun
, p. 1780 - 1784,5 (2020/07/30)
A novel series of 3-cinnamoyl-4-hydroxy-2Hchromen-2-ones were designed, synthesized and screened for antiplasmodial activity. Eleven compounds of the series exhibited micromolar potency against chloroquine sensitive and chloroquine resistant strains. The most potent compound 4-hydroxy-3-(3-(4- nitrophenyl)acryloyl)-2Hchromen-2-one showed inhibitory potency (IC 50) of 3.1 and 4 μg/ml against chloroquine sensitive and chloroquine resistant strains, respectively. A structure activity relationship study was performed by correlating the effect of substituents with the antimalarial activity of the title compounds. The novel 3-cinnamoyl-4-hydroxy- 2H-chromen-2-ones reported here should be good lead for further development of antimalarial agents that can overcome resistance.