57352-25-7

Basic information

• Product Name: Cyclohexanecarbonitrile, 3-oxo-1-phenyl-
• Synonyms: 3-Cyano-3-phenylcyclohexanon;3-oxo-1-phenylcyclohexanecarbonitrile;Cyclohexanecarbonitrile,3-oxo-1-phenyl
• CAS NO: 57352-25-7
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol File: 57352-25-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarbonitrile, 3-oxo-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonitrile, 3-oxo-1-phenyl-(57352-25-7)
• EPA Substance Registry System: Cyclohexanecarbonitrile, 3-oxo-1-phenyl-(57352-25-7)

Safety Data

• Hazardous Substances Data: 57352-25-7(Hazardous Substances Data)

Upstream product

• 10345-87-6 3-phenylcyclohex-2-enone 
• 151-50-8 potassium cyanide 
• 100-58-3 phenylmagnesium bromide 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 143-33-9 sodium cyanide 

Downstream Products

• 1429045-46-4 C₂₂H₂₃F₆NO 
• 1429045-47-5 C₂₂H₂₃F₆NO 
• 1429045-48-6 C₂₃H₂₅F₆NO 
• 1429045-49-7 C₂₃H₂₅F₆NO 
• 874375-80-1 3,3-ethylenedioxy-1-phenylcyclohexanecarbaldehyde 
• 874375-81-2 (3,3-ethylenedioxy-1-phenylcyclohexyl)methanol 
• 874375-82-3 1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene 
• 874375-83-4 3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclohexanone 
• 874453-48-2 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepan-2-one 
• 874453-49-3 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepan-2-one 
• 874453-51-7 6-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-6-phenylazepan-2-one 
• 874453-50-6 6-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-6-phenylazepan-2-one 
• 874454-08-7 (R)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane 
• 874454-07-6 (S)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane 

Relevant articles and documents

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression

This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.

Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists

The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

Azabicylcoalkanes as analgetics. II. An improved synthesis of 1 phenyl 6 azabicyclo[3,2,1]octane derivatives

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