57355-35-8

Basic information

• Product Name: 2-hydroxy-3-methoxy-6 beta-naltrexol
• Synonyms: 2-hydroxy-3-methoxy-6 beta-naltrexol;2-Hydroxy-3-O-methyl-6β-naltrexol;(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,10-triol
• CAS NO: 57355-35-8
• Molecular Formula: C21H27NO5
• Molecular Weight: 373.44278
• Mol File: 57355-35-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 592.3°Cat760mmHg
• Flash Point: 312°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 7.07E-15mmHg at 25°C
• Refractive Index: 1.698
• PKA: 9.69±0.60(Predicted)
• CAS DataBase Reference: 2-hydroxy-3-methoxy-6 beta-naltrexol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-methoxy-6 beta-naltrexol(57355-35-8)
• EPA Substance Registry System: 2-hydroxy-3-methoxy-6 beta-naltrexol(57355-35-8)

Safety Data

• Hazardous Substances Data: 57355-35-8(Hazardous Substances Data)

Usage

Description

2-Hydroxy-3-methoxy-6 beta-naltrexol, also known as 2-Hydroxy-3-O-methyl-6β-naltrexol, is a metabolite of Naltrexone (N285750), an opioid receptor antagonist. It is derived from the metabolism of Naltrexone, which is a medication primarily used to treat opioid and alcohol dependence. 2-hydroxy-3-methoxy-6 beta-naltrexol has potential applications in various fields due to its unique chemical properties and its connection to the opioid system.

Uses

Used in Pharmaceutical Applications:
2-Hydroxy-3-methoxy-6 beta-naltrexol is used as a pharmaceutical compound for its potential role in the treatment of opioid and alcohol dependence. As a metabolite of Naltrexone, it may contribute to the overall efficacy of the medication in blocking the effects of opioids and reducing cravings for alcohol.
Used in Research and Development:
In the field of research, 2-Hydroxy-3-methoxy-6 beta-naltrexol can be used as a research tool to study the mechanisms of opioid receptor antagonism and its potential effects on the central nervous system. This may lead to the development of new therapeutic strategies for the treatment of addiction and other related disorders.
Used in Drug Delivery Systems:
Similar to Gallotannin, 2-Hydroxy-3-methoxy-6 beta-naltrexol could potentially be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. This may involve the use of nanoparticles or other advanced drug delivery technologies to enhance the compound's effectiveness in treating specific conditions.
Used in Analytical Chemistry:
As a metabolite of Naltrexone, 2-Hydroxy-3-methoxy-6 beta-naltrexol can be used in analytical chemistry for the detection and quantification of Naltrexone in biological samples. This can be useful in monitoring the levels of the drug in patients undergoing treatment for opioid or alcohol dependence, ensuring proper dosing and adherence to the treatment regimen.

InChI:InChI=1/C21H27NO5/c1-26-17-14(24)8-12-9-15-21(25)5-4-13(23)19-20(21,16(12)18(17)27-19)6-7-22(15)10-11-2-3-11/h8,11,13,15,19,23-25H,2-7,9-10H2,1H3/t13-,15-,19+,20+,21-/m1/s1