573650-50-7Relevant articles and documents
Synthesis of water-Soluble prodrugs of BMS-191011: A maxi-K channel opener targeted for post-stroke neuroprotection
Hewawasam, Piyasena,Ding, Min,Chen, Nathan,King, Dalton,Knipe, Jay,Pajor, Lorraine,Ortiz, Astrid,Gribkoff, Valentin K.,Starrett, John
, p. 1695 - 1698 (2007/10/03)
A variety of water-soluble prodrugs of BMS-191011 was synthesized and evaluated for solution state stability and rate of conversion to BMS-191011 in rat and human plasma. The deoxycarnitine ester prodrug (11c) was selected for clinical evaluation based on