57367-56-3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 121742-94-7 t-butyl 3-methoxycarbonyl-6-phenylhexa-3,5-dienoate 
• 115061-12-6 4-t-butyl 1-methyl (E)-2-(4-acetoxy-3-methoxyphenylmethylene)butadienoate 
• 115061-15-9 4-t-butyl 1-methyl (E)-2-(4-acetoxy-3,5-dimethoxyphenylmethylene)butadienoate 
• 121742-95-8 t-butyl 3-methoxycarbonyl-5-phenylhepta-3,5-dienoate 
• 115046-50-9 2-[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 115061-13-7 4-t-butyl 1-methyl (E)-2-(2-acetoxy-3-methoxyphenylmethylene)butadienoate 
• 122849-60-9 2-[1-(2,3,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 115046-51-0 2-[1-(2-Bromo-5-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 121742-96-9 t-butyl 5-(2-bromo-5-nitrophenyl)-3-methoxycarbonylhepta-3,5-dienoate 
• 115046-48-5 2-[1-(3,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 121742-93-6 t-butyl 3-methoxycarbonyl-5-methyl-6-phenylhexa-3,5-dienoate 
• 121743-02-0 cinnamilidenesuccinic acid 1-methyl ester 
• 121743-00-8 2-(2-methyl-3-phenylallylidene)succinic acid 1-methyl ester 
• 121743-03-1 5-(2-bromo-5-nitrophenyl)-3-methoxycarbonylhepta-3,5-dienoic acid 

Relevant academic research and scientific papers

SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS

The present invention provides a compound of formula I' or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Method of preparing optically active homo-beta-amino acids

The present invention is directed to synthesis of homo-β-amino acids of an optical purity sufficient to exhibit optical activity wherein Curtius rearrangement of 3-mono-substituted succinate acid half ester of an optical purity sufficient to exhibit optical activity is affected and the incipient isocyanate is trapped with a primary or secondary alcohol. The resulting carbamate-protected homo-β-amino esters are then saponified to produce the corresponding carbamate-protected homo-β-amino acids which are deprotected to yield homo-β-amino acids of an optical purity sufficient to exhibit optical activity.