573675-60-2

Basic information

• Product Name: 3-FLUORO-2-(TRIBUTYLSTANNYL)PYRIDINE
• Synonyms: 3-FLUORO-2-(TRIBUTYLSTANNYL)PYRIDINE;(3-Fluoropyridin-2-yl)tributylstannane;2-(Tributylstannyl)-3-fluoropyridine;3-Fluoro-2-(tributylstannanyl)pyridine;3-Fluoro-2-(tributylstannyl);tributyl-(3-fluoropyridin-2-yl)stannane
• CAS NO: 573675-60-2
• Molecular Formula: C₁₇H₃₀FNSn
• Molecular Weight: 386.139
• Product Categories: Stannanes
• Mol File: 573675-60-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 372.522°C at 760 mmHg
• Flash Point: 179.095°C
• Appearance: /
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.78±0.29(Predicted)
• CAS DataBase Reference: 3-FLUORO-2-(TRIBUTYLSTANNYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-2-(TRIBUTYLSTANNYL)PYRIDINE(573675-60-2)
• EPA Substance Registry System: 3-FLUORO-2-(TRIBUTYLSTANNYL)PYRIDINE(573675-60-2)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 573675-60-2(Hazardous Substances Data)

Usage

Description

3-Fluoro-2-(tributylstannyl)pyridine is an organostannane compound characterized by the presence of a fluorine atom at the 3-position and a tributylstannyl group at the 2-position of the pyridine ring. This unique molecular structure endows it with specific chemical properties and reactivity, making it a valuable intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
3-Fluoro-2-(tributylstannyl)pyridine is used as a synthetic intermediate for the preparation of substituted quinazolin-4-ylamine analogs. These analogs serve as VR1 capsaicin receptor antagonists, which are crucial in the development of novel pain relief medications. By targeting the VR1 receptor, these antagonists can effectively alleviate pain sensations, offering a promising therapeutic approach for patients suffering from various types of pain.

InChI:InChI=1/C5H3FN.3C4H9.Sn/c6-5-2-1-3-7-4-5;3*1-3-4-2;/h1-3H;3*1,3-4H2,2H3;/rC17H30FNSn/c1-4-7-13-20(14-8-5-2,15-9-6-3)17-16(18)11-10-12-19-17/h10-12H,4-9,13-15H2,1-3H3

Upstream product

• 40273-45-8 2-bromo-3-fluoropyridine 
• 813-19-4 bis(tri-n-butyltin) 
• 1461-22-9 tributyltin chloride 
• 372-47-4 3-Fluoropyridine 

Downstream Products

• 1414956-38-9 (R)-(1-cyclopropylethylamino)-7-(4-(3-fluoropyridin-2-yl)-2-methoxyphenyl)cinnoline-3-carboxamide 
• 1312946-54-5 (S)-2-((3-(3-fluoropyridin-2-yl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)oxy)-N-(1-(p-tolyl)ethyl)acetamide 
• 765917-24-6 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(3-fluoropyridin-2-yl)-[1,2,4]triazine 
• 765917-20-2 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine 
• 765917-19-9 3-(2,4-difluorophenyl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine 

Relevant articles and documents

INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE

Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

BIPYRIDINE COMPOUND AND USE OF SAME FOR NOXIOUS ARTHROPOD CONTROL

Provided is a bipyridine compound that exhibits an excellent controlling effect against noxious arthropods. In particular, provided is a bipyridine compound of formula (I) or an N-oxide thereof in which the variable groups are as defined in the specification. Also provided are compositions containing the biypridine compound or an N-oxide thereof, and methods of using such compounds and compositions to control noxious arthropods.

PEST CONTROL COMPOSITION AND APPLICATIONS THEREOF

PROBLEM TO BE SOLVED: To provide a pest control composition having excellent efficacy of pest control. SOLUTION: A pest control composition comprises a compound represented by formula (1) and one or more compounds selected from group (a) or group (b). [In the formula, each symbol represents definition described in the specification.] SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT