573675-60-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-2-(tributylstannyl)pyridine is used as a synthetic intermediate for the preparation of substituted quinazolin-4-ylamine analogs. These analogs serve as VR1 capsaicin receptor antagonists, which are crucial in the development of novel pain relief medications. By targeting the VR1 receptor, these antagonists can effectively alleviate pain sensations, offering a promising therapeutic approach for patients suffering from various types of pain.

InChI:InChI=1/C5H3FN.3C4H9.Sn/c6-5-2-1-3-7-4-5;3*1-3-4-2;/h1-3H;3*1,3-4H2,2H3;/rC17H30FNSn/c1-4-7-13-20(14-8-5-2,15-9-6-3)17-16(18)11-10-12-19-17/h10-12H,4-9,13-15H2,1-3H3

Upstream product

• 372-47-4 3-Fluoropyridine 
• 1461-22-9 tributyltin chloride 
• 40273-45-8 2-bromo-3-fluoropyridine 
• 813-19-4 bis(tri-n-butyltin) 

Downstream Products

• 1414956-38-9 (R)-(1-cyclopropylethylamino)-7-(4-(3-fluoropyridin-2-yl)-2-methoxyphenyl)cinnoline-3-carboxamide 
• 1312946-54-5 (S)-2-((3-(3-fluoropyridin-2-yl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)oxy)-N-(1-(p-tolyl)ethyl)acetamide 
• 765917-24-6 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(3-fluoropyridin-2-yl)-[1,2,4]triazine 
• 765917-20-2 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine 
• 765917-19-9 3-(2,4-difluorophenyl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine 

Relevant academic research and scientific papers

INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE

Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

IDENTIFICATION AND USE OF KRAS INHIBITORS

The present invention relates to compounds of formula (1) in which A, U and R1 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant KRAS signaling, as a sole agent or in combination with other active ingredients.

BIPYRIDINE COMPOUND AND USE OF SAME FOR NOXIOUS ARTHROPOD CONTROL

Provided is a bipyridine compound that exhibits an excellent controlling effect against noxious arthropods. In particular, provided is a bipyridine compound of formula (I) or an N-oxide thereof in which the variable groups are as defined in the specification. Also provided are compositions containing the biypridine compound or an N-oxide thereof, and methods of using such compounds and compositions to control noxious arthropods.

Pest control composition and pest control method

PROBLEM TO BE SOLVED: To provide a pest control composition having excellent pest control effect. SOLUTION: A pest control composition contains a bipyridine compound represented by the following formula (I) [where each symbol represents a definition in the specifications] or an N oxide compound thereof, and at least one compound selected from the following groups a to d. The group a is: bactericides. The group b is: insecticidal, acaricidal, and nematicidal agents. The group c is: phytotoxicity reducing agents. The group d is: plant growth regulators. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

PEST CONTROL COMPOSITION AND APPLICATIONS THEREOF

PROBLEM TO BE SOLVED: To provide a pest control composition having excellent efficacy of pest control. SOLUTION: A pest control composition comprises a compound represented by formula (1) and one or more compounds selected from group (a) or group (b). [In the formula, each symbol represents definition described in the specification.] SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

PYRIMIDINONE COMPOUND

A pyrimidinone compound represented by formula (1): wherein: A1 represents a nitrogen atom or a CR4; A2 represents a nitrogen atom and A3 represents a CR3b, or A2 represents a CR3a and A3 represents a nitrogen atom; Q represents an oxygen atom or a sulfur atom; G represents a C2-C10 chain hydrocarbon group having one or more halogen atoms, etc.; R1 represents a C1-C6 chain hydrocarbon group optionally having one or more halogen atoms; R2 represents a C1-C6 chain hydrocarbon group optionally having one or more halogen atoms, etc.; R4 represents a hydrogen atom, etc.; R3, R3a, and R3b represent independently of each other a hydrogen atom, etc.; n represents 0, 1, or 2; and p represents 0, 1, 2, or 3 has an excellent efficacy for controlling harmful arthropods.

Compounds and Uses Thereof - 848

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, Rsu

5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression

The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Z represents hydrogen, halogen, cyano, cyanomethyl, trifluoromethyl, nitro, hydroxy, hydroxy(C1-6)alkyl, C1-6 alkoxy, C1-6 alkoxy(C1-6)alkyl, trifluoromethoxy, trifluoromethylthio, trifluoromethanesulfinyl, formyl, C2-6 alkoxycarbonyl, oxopyrrolidinyl, or an optionally substituted aryl, heteroaryl or heteroaryl(C1-6)alkoxy group; and R1 represents aryl or heteroaryl, either of which groups may be optionally substituted; pharmaceutical compositions comprising it, its use in therapy and methods of treatment of anxiety and/or depression using it.