573675-87-3Relevant academic research and scientific papers
Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution
Blum, Charles A.,Zheng, Xiaozhang,Brielmann, Harry,Hodgetts, Kevin J.,Bakthavatchalam, Rajagopal,Chandrasekhar, Jayaraman,Krause, James E.,Cortright, Daniel,Matson, David,Crandall, Marci,Ngo, Chu K.,Fung, Lawrence,Day, Marta,Kershaw, Mark,De Lombaert, Stephane,Chenard, Bertrand L.
scheme or table, p. 4573 - 4577 (2009/04/06)
A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist 2 led to the discovery of compound 18. In rats, compound 18 is readily absorbed following oral dosing and demonstrates excellent in vivo potency and efficacy in an acute inflammator
Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
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Page/Page column 18, (2010/02/14)
Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions assoc
SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES
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, (2008/06/13)
Substituted bipheny1-4-carboxylic acid arylamide analogues capable of modulating receptor activity, are provided. Such ligands may be used to modulate receptor activity in viva or in vitro, and are particularly useful in the treatment of pain and other co
2-SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS
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Page 55, (2010/02/07)
Certain 2-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathologi
