573692-80-5

Basic information

• Product Name: Heptanoic acid, 2-diazo-3,6-dioxo-, 1,1-dimethylethyl ester
• CAS NO: 573692-80-5
• Molecular Formula: C11H16N2O4
• Molecular Weight: 240.259
• Mol File: 573692-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Heptanoic acid, 2-diazo-3,6-dioxo-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Heptanoic acid, 2-diazo-3,6-dioxo-, 1,1-dimethylethyl ester(573692-80-5)
• EPA Substance Registry System: Heptanoic acid, 2-diazo-3,6-dioxo-, 1,1-dimethylethyl ester(573692-80-5)

Safety Data

• Hazardous Substances Data: 573692-80-5(Hazardous Substances Data)

Upstream product

• 40052-13-9 mono-tert-butyl malonate 

Relevant articles and documents

Rhodium(II)-catalyzed enantioselective synthesis of troponoids

We report a rhodium(II)-catalyzed highly enantioselective 1,3-dipolar cycloaddition reaction between the carbonyl moiety of tropone and carbonyl ylides to afford troponoids in good to high yields with excellent enantioselectivity. We demonstrate that α-diazoketone-derived carbonyl ylides, in contrast to carbonyl ylides derived from diazodiketoesters, undergo [6+3] cycloaddition reactions with tropone to yield the corresponding bridged heterocycles with excellent stereoselectivity. Decisive dipoles: In the rhodium(II)-catalyzed asymmetric 1,3-dipolar cycloaddition of tropone with carbonyl ylides, a programmable chemoselective reaction with the keto group or the 6 π system of tropone was controlled by the substrate (see scheme). The developed method enables the synthesis of complex products in highly enantiomerically enriched form.