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2,7-di(piperidin-1-yl)-4-(pyrrolidin-1-yl)pyrimido[4,5-d]pyrimidine, also known as UNC667, is a small molecule inhibitor that specifically targets the protein lysine methyltransferase 7 (KMT7). This enzyme is involved in the methylation of histone proteins, a process that influences gene expression and cellular functions. UNC667 has demonstrated the ability to reduce histone methylation levels, thereby inducing alterations in gene expression and cellular activity. Its potential therapeutic applications are currently under investigation for the treatment of diseases where abnormal histone methylation plays a role, such as cancer and neurological disorders.

5737-67-7

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5737-67-7 Usage

Uses

Used in Pharmaceutical Industry:
2,7-di(piperidin-1-yl)-4-(pyrrolidin-1-yl)pyrimido[4,5-d]pyrimidine is used as a therapeutic agent for the treatment of various diseases, including cancer and neurological disorders. The application reason is its ability to inhibit the KMT7 enzyme, which is implicated in the progression of these diseases through its role in histone methylation.
Used in Cancer Research:
In the field of cancer research, 2,7-di(piperidin-1-yl)-4-(pyrrolidin-1-yl)pyrimido[4,5-d]pyrimidine is used as a potential anti-cancer drug. The application reason is its capacity to reduce histone methylation levels, which can lead to changes in gene expression that may inhibit tumor growth and progression.
Used in Neurological Research:
In the context of neurological research, 2,7-di(piperidin-1-yl)-4-(pyrrolidin-1-yl)pyrimido[4,5-d]pyrimidine is utilized as a candidate for the treatment of neurological disorders. The application reason is its potential to modulate histone methylation, which may have therapeutic effects on conditions where aberrant histone methylation is implicated.
Further research is ongoing to evaluate the pharmaceutical potential and safety profile of UNC667, with the aim of determining its efficacy and suitability for clinical use in treating the aforementioned conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 5737-67-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,3 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5737-67:
(6*5)+(5*7)+(4*3)+(3*7)+(2*6)+(1*7)=117
117 % 10 = 7
So 5737-67-7 is a valid CAS Registry Number.

5737-67-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,7-di(piperidin-1-yl)-4-pyrrolidin-1-ylpyrimido[4,5-d]pyrimidine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:5737-67-7 SDS

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