573704-64-0Relevant academic research and scientific papers
CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY
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Page/Page column 60-61, (2012/01/06)
The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.
QUINAZOLINE DERIVATIVES
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Page/Page column 118, (2008/06/13)
The invention concerns quinazoline derivatives of Formula (I) wherein each of R1, R3, R20, X1, X2, Z, W, (a) and (q) have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of turnours which are sensitive to inhibition of erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.
Synthesis of potent oxindole CDK2 inhibitors
Dermatakis, Apos,Luk, Kin-Chun,DePinto, Wanda
, p. 1873 - 1881 (2007/10/03)
A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative to th
