573711-01-0Relevant academic research and scientific papers
Diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates
Novikov, Alexei V.,Sabahi, Amir,Nyong, Abijah M.,Rainier, Jon D.
, p. 911 - 915 (2003)
We have examined the coupling reactions of 2-thioindoles with vinyl diazoacetates in the presence of Rh(II) catalysts. While attempted enantio- and/or diastereoselective couplings using chiral catalysts and/or chiral auxiliaries on the vinyl diazoacetate have been largely unsuccessful, substrates having resident chirality on fused thiopyrans gave thioindolines with moderate to high diastereoselectivities.
