57383-80-9Relevant articles and documents
Efficient synthesis method of 2,3-dibromophenol or derivative thereof
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Paragraph 0020-0028, (2020/04/29)
The invention relates to an efficient synthesis method of 2,3-dibromophenol or a derivative thereof. The method comprises the following steps: adding o-dibromobenzene or an o-dibromobenzene derivativeand tert-butyl hydroperoxide into water, adding a copper catalyst, reacting at room temperature for 6-12 hours, and separating and purifying to obtain the 2,3-dibromophenol or the 2,3-dibromophenol derivative. Compared with the method in the prior art, the method of the invention has characteristics of simple and environmentally-friendly synthesis process, excellent selectivity, high yield and simple reaction post-treatment, is environment-friendly and safe by taking water as a solvent, and has great application potential in drug synthesis, natural product synthesis and the like.
Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles
Guilarte, Veronica,Castroviejo, M. Pilar,Garcia-Garcia, Patricia,Fernandez-Rodriguez, Manuel A.,Sanz, Roberto
, p. 3416 - 3437 (2011/06/28)
2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.
Selective and one-pot formation of phenols by anodic oxidation
Fujimoto, Kazuo,Tokuda, Yuichiro,Maekawa, Hirofumi,Matsubara, Yoshiharu,Mizuno, Takumi,Nishiguchi, Ikuzo
, p. 3889 - 3896 (2007/10/03)
Direct monohydroxylation of benzene and substituted benzenes was successfully performed by anodic oxidation to form the corresponding phenol derivatives in good yields. The anodic oxidation was generally carried out in a mixed solvent of trifluoroacetic acid and dichloromethane containing triethylamine using a divided cell equipped with a platinum plate as the anode, a carbon rod as the cathode. Benzene derivatives having electron withdrawing groups were suitable for the present electrochemical oxidation. It was clarified that aryltrifluoroacetates were formed as the initial products from the reaction of the radical cations, generated by one electron transfer from the substrates, with trifluoroacetic acid, followed by hydrolysis during work-up to give the corresponding phenols.
