57385-16-7

Basic information

• Product Name: 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI)
• Synonyms: 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI);4-Ethynyltetrahydropyran-4-ol;4-ethynyloxan-4-ol;4-Ethynyltetrahydro-2H-pyran-4-ol
• CAS NO: 57385-16-7
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.1531
• Mol File: 57385-16-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 62-63 °C
• Boiling Point: 214.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• PKA: 12.65±0.20(Predicted)
• CAS DataBase Reference: 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI)(57385-16-7)
• EPA Substance Registry System: 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI)(57385-16-7)

Safety Data

• Hazardous Substances Data: 57385-16-7(Hazardous Substances Data)

Usage

General Description

2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI) is a chemical compound with the molecular formula C7H8O. It belongs to the class of organic compounds known as pyranols, which are compounds containing a pyran ring, which is a six-membered heterocyclic ring with five carbon atoms and one oxygen atom. The ethynyl group in the compound indicates the presence of a carbon-carbon triple bond, which gives the compound unique properties and reactivity. 2H-Pyran-4-ol, 4-ethynyltetrahydro- (9CI) is used in organic synthesis and pharmaceutical research due to its potential applications in the development of new drugs and materials.

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 65032-27-1 ethynylmagnesium chloride 
• 1044277-44-2 4-((trimethylsilyl)ethynyl)tetrahydro-2H-pyran-4-ol 
• 108-94-1 cyclohexanone 
• 4301-14-8 acetylenemagnesium bromide 
• 1066-54-2 trimethylsilylacetylene 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 

Downstream Products

• 710321-81-6 3-cyclopentyl-N-[5-(4-hydroxy-tetrahydro-pyran-4-ylethynyl)-pyrazin-2-yl]-2(R)-(4-methanesulfonyl-3-methyl-phenyl)-propionamide 
• 710321-68-9 3-cyclopentyl-N-5-[(4-hydroxy-tetrahydropyran-4-yl-ethynyl)pyrazin-2-yl]-2(R)-(4-methanesulfonyl-phenyl)-propionamide 
• 710321-73-6 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-[5-(4-hydroxy-tetrahydropyran-4-yl-ethyl)-pyrazin-2-yl]-propionamide 
• 1449379-36-5 4-((2-azidophenyl)ethynyl)tetrahydro-2H-pyran-4-yl acetate 
• 1449379-35-4 C₁₃H₁₃N₃O₂ 
• 1449379-34-3 C₁₃H₁₅NO₂ 

Relevant articles and documents

NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

A compound selectively inhibiting Nav1.7 over Nav1.5 is provided. A heteroaromatic amide derivative or salt thereof showing high efficacy for various diseases associated with Nav1.7 such as pain, represented by the general formula (I) [wherein, X1-X2 is N-C or C-N, Y1 , Y2, Y3 and Y4 are -CH2-, -CR4aH- or -O- and so on, Z1 is-O- and so on, ring A is a 3- to 7-membered monocyclic aromatic ring and so on, R1a and R1b are a hydrogen atom or a halogen atom and so on, R2 is a hydrogen atom and so on, R3a, R3b and R3c are a hydrogen atom or an optionally substituted C1-C6 haloalkyl group and so on, R4a, R4b and R4c are, an optionally substituted C1-C6 haloalkyl group or C1-C6 haloalkoxy group and so on, R5a is a hydrogen atom and so on, R5a and R5b together form -CH2O- and so on, R6a and R6b are a hydrogen atom and so on, n is 1 or 2.].

Halogen-Substituted Allenyl Ketones through Ring Opening of Nonstrained Cycloalkanols

An efficient synthesis of halogen-substituted allenyl ketones via Ag-catalyzed oxidative ring opening of allenyl cyclic alcohols under mild reaction conditions has been achieved. The reaction features a wide substrate scope and excellent regioselectivity. The synthetic potential of the products has been demonstrated by their conversion to stereodefined alkenes and heterocyclic compounds.

Synthesis of Bridged Azacycles and Propellanes via Nitrene/Alkyne Cascades

A nitrene/alkyne cascade reaction terminating in C-H bond insertion to form functionalized bridged azacycles from carbonazidates is presented. Due to an initial Huisgen cyclization, all carbonazidates reacted with the alkyne in an exo mode in contrast to the use of sulfamate esters, which react predominately in an endo mode. Substrates with different ring sizes as well as different aryl and heteroaryl groups were also explored. Variation of the nitrene tether showed that 7-membered rings were the maximum ring size to be formed by nitrene attack on the alkyne. Examples incorporating stereocenters on the carbonazidate's tether induced diasteroselectivity in the formation of the bridged ring and two new stereocenters. Additionally, propellanes containing aminals, hemiaminals, and thioaminals formed from the bridged azacycles in the same reaction via an acid-promoted rearrangement.