573968-41-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue
Mak, Chi Ching,Le, Van-Duc,Lin, Ying-Chuan,Elder, John H,Wong, Chi-Huey
, p. 219 - 222 (2001)
A series of norstatine-based HIV/FIV protease inhibitors incorporating a 15-membered macrocycle as a mimic of the tripeptide (Ala-Val-Phe), a motif with a small P3′ residue effective against the FIV protease and the drug-resistant HIV proteases, has been
Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases
Mak, Chi Ching,Brik, Ashraf,Lerner, Danica L.,Elder, John H.,Morris, Garrett M.,Olson, Arthur J.,Wong, Chi-Huey
, p. 2025 - 2040 (2007/10/03)
Based on the substrate transition state and our strategy to tackle the problem of drug resistance, a series of HIV/FIV protease (HIV/FIV PR) monocyclic inhibitors incorporating a 15- or 17-membered macrocycle with an equivalent P3 or P3′ group and a uniqu
