573968-52-2Relevant academic research and scientific papers
Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases
Mak, Chi Ching,Brik, Ashraf,Lerner, Danica L.,Elder, John H.,Morris, Garrett M.,Olson, Arthur J.,Wong, Chi-Huey
, p. 2025 - 2040 (2007/10/03)
Based on the substrate transition state and our strategy to tackle the problem of drug resistance, a series of HIV/FIV protease (HIV/FIV PR) monocyclic inhibitors incorporating a 15- or 17-membered macrocycle with an equivalent P3 or P3′ group and a uniqu
