573976-51-9Relevant academic research and scientific papers
The Synthesis and Biological Evaluation of N-Substituted 1H-Benzimidazol-2-yl-1H-pyrazole-3,5-diamines
Jedink, Luk,Krytof, Vladimr,Canka, Petr
, p. 499 - 507 (2016)
The synthesis of 1H-benzimidazol-2-yl-1H-pyrazole-3,5-diamines has been developed. Synthesized bisheteroaryls contain two privileged medicinal scaffolds, aminopyrazole and benzimidazole, with two diversity positions at N1 of benzimidazole and C3 of pyrazo
Synthesis of benzimidazole ketene N,S-acetals and their reactions with nucleophiles
Elgemeie, Galal H.,Ali, Hosny A.,Elghandour, Ahmed H.,Hussein, Ahmed M.
, p. 555 - 562 (2007/10/03)
The novel ketene thioacetal 4 and ketene N,S-acetal 5 were readily prepared by the reaction of 2-cyanomethylbenzimidazole with either carbon disulfide or phenyl isothiocyanate in the presence of a base, followed by alkylation of the produced salts with methyl iodide. The reaction of compounds 4 and 5 with hydrazines afforded different benzimidazolyl substituted pyrazoles.
