573982-25-9

Basic information

• Product Name: C₂₆H₂₂F₅NO₃S
• CAS NO: 573982-25-9
• Molecular Weight: 523.524
• Mol File: 573982-25-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₂F₅NO₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₂F₅NO₃S(573982-25-9)
• EPA Substance Registry System: C₂₆H₂₂F₅NO₃S(573982-25-9)

Safety Data

• Hazardous Substances Data: 573982-25-9(Hazardous Substances Data)

Upstream product

• 573982-80-6 N-isobutyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide 
• 302912-34-1 2,4-difluoroethynylbenzene 

Relevant articles and documents

Discovery and optimization of a series of liver X receptor antagonists

The present report describes our efforts to convert an existing LXR agonist into an LXR antagonist using a structure-based approach. A series of benzenesulfonamides was synthesized based on structural modification of a known LXR agonist and was determined to be potent dual liver X receptor (LXR α/β) ligands. Herein we report the identification of compound 54 as the first reported LXR antagonist that is suitable for pharmacological in vivo evaluation in rodents.