57412-02-9Relevant academic research and scientific papers
A "turn-on" fluorescent probe used for the specific recognition of intracellular GSH and its application in bioimaging
Pang, Lanfang,Zhou, Yanmei,Wang, Enze,Yu, Fang,Zhou, Hua,Gao, Wenli
, p. 16467 - 16473 (2016)
We have designed and synthesized a carbazole-based fluorescent probe (CZ-Nm) for the specific recognition of GSH over Cys and Hcy. The probe is almost non-fluorescent owing to the photoinduced electron transfer (PET) process from the carbazole fluorophore to the nitroolefin moiety. Upon treatment with GSH, owing to the Michael addition of GSH to the double bond of the nitroolefin moiety, the probe shows a fluorescence enhancement and absorption change. The CZ-Nm probe displays desirable properties such as acting as a "naked eye" probe, a wide linear range of 0-0.01 M, high sensitivity, and strong anti-jamming capability. More importantly, the probe can also be successfully applied to the detection of intracellular GSH with a bright fluorescence signal, good cell permeability and bio-compatibility.
p-TsOH-mediated, Versatile, and Efficient Approach for the Synthesis of Triazolyl-Carbazoles from Nitrovinylcarbazoles and Azide via 1, 3-Dipolar Cycloaddition
Avula, Vijay Kumar Reddy,Vallela, Swetha,Anireddy, Jaya Shree,Chamarthi, Naga Raju
, p. 1361 - 1368 (2017/03/27)
An efficient method for the synthesis of N-alkylated 3-(1-benzyl-1H-1,2,3-triazole-4-yl)-9H-carbazoles (5, 6, 7, 8, 9, 10) and 9-ethyl-3,6-di(1H-1,2,3-triazole-4-yl)-9H-carbazole (13) has been developed from nitroolefines. The effects of catalyst and solvent on these reactions have been investigated. p-TsOH-THF was found to be the best system for this reaction. Various triazolyl-carbazoles were prepared in good to excellent yields.
Substituted Carbazoles-A New Class of Anthelmintic Agent
Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
, p. 1268 - 1276 (2016/11/25)
A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
FACILE SYNTHESIS OF NOVEL CARBAZOLES THROUGH HETEROCYCLIZATION REACTIONS AND THEIR ANTIMICROBIAL ACTIVITY
Berghot, Moged Ahmed,Badawy, Doria Saleh,Moawad, Evelin Boshra
, p. 377 - 386 (2007/10/03)
9-Ethylcarbazole binary attached to the position 3 with some heterocyclic systems such as pyrazole, pyrazolinone, pyrazoline, thiazolidinone, azetidinone, triazoline, benzimidazole, benzoxazole, benzothiazole, oxazolidinone, thiouracil and furane were synthesized.The structures of the synthesized compounds have been confirmed by analytical and spectral methods.Some of these compounds were screened to test their antimicrobial properties.
