57428-53-2Relevant academic research and scientific papers
Synthesis of 2,6-dioxo-1,2,3,4,5,6-hexahydroindoles by acid-catalyzed cyclization of acetal-protected (2,4-dioxocyclohex-l-yl)acetamides and their transformation into 5,8,9,10-tetrahydro-6H-indolo[2,1-a]isoquinolin-9-ones
Juma, Benard,Adeel, Muhammad,Villinger, Alexander,Reinke, Helmut,Spannenberg, Anke,Fischer, Christine,Langer, Peter
supporting information; experimental part, p. 1073 - 1079 (2009/12/05)
Acetal-protected (2,4-dioxocyclohex-1-yl)-acetic acids were prepared by allylation of dilithiated 1,3-cyclohexane-1,3-diones, protection of the carbon-yl groups and oxidation of the alkene moiety. Their reaction with amines afforded the corresponding amides which were transformed, by acid-catalyzed cyclization, into various 2,6-dioxo-1,2,3,4,5,6-hexahy-droindoles. The reaction of the latter with triflic acid resulted in the formation of novel 5,8,9,10-tetrahy-dro-6H-indolo[2,1-a]isoquinolin-9-ones.
Free radical reactions for heterocycle synthesis. Part 7: 2-Bromobenzoic acids as building blocks in the construction of spirobenzolactones and spirobenzolactams
Zhang, Wei,Pugh, Georgia
, p. 4237 - 4247 (2007/10/03)
A straightforward 2-step parallel synthesis for structurally diversified spiro compounds is developed. 2-Bromobenzoic acids are used as common building blocks to couple with a series of conjugated enoles or enamines. Sequential intramolecular free radical
Free radical reactions for heterocycle synthesis. Part 5: Formation of novel bridged spirolactones by double cyclizations
Zhang, Wei,Pugh, Georgia
, p. 5617 - 5620 (2007/10/03)
Novel bridged spirolactones have been synthesized via double radical cyclization of enol ester radicals.
Direct 4-Alkylation of 1,3-Cyclohexanediones via Dianionic Species
Berry, Nicola M.,Darey, Mark C. P.,Harwood, Laurence M.
, p. 476 - 480 (2007/10/02)
1,3-Cyclohexanediones are directly alkylated at the 4 position via dianionic species generated at -78 deg C using lithium diisopropylamine/hexamethylphosphoric triamide.Acetylation of the reaction products at room temperature yields the 3-acetoxy-6-alkylc
Pyrazolopyridine cycloalkanones and process for their preparation
-
, (2008/06/13)
Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclopenta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyrazolo[4,3-e]pyridinones, useful as anxiolytics having reduced side effects, are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.
Synthesis of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones
Piers, Edward,Grierson, John R.,Lau, Cheuk Kun,Nagakura, Isao
, p. 210 - 223 (2007/10/02)
A new, efficient method for the preparation of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones is described.The method involves the reaction of β-diketones or α-hydroxymethylenecycloalkanones with triphenylphosphine dihalides in the presence of trie
