57433-58-6Relevant academic research and scientific papers
Metal-free nitrative cyclization of N-aryl imines with tert-butyl nitrite: Dehydrogenative access to 3-nitroindoles
Deng, Guo-Bo,Zhang, Jia-Ling,Liu, Yan-Yun,Liu, Bang,Yang, Xu-Heng,Li, Jin-Heng
, p. 1886 - 1888 (2015)
We describe here a new metal-free route for the synthesis of 3-nitroindoles by the nitrative cyclization of N-aryl imines with tert-butyl nitrite. The radical transformation allows the assembly of the indole framework through oxidative cleavage of multi C-H bonds, a nitration, cyclization and isomerization cascade.
