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Premazepam, a benzodiazepine derivative medication, is primarily known for its anxiolytic, sedative, and hypnotic properties. It functions as a prodrug for the active metabolite desmethyldiazepam, which enhances the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system. This results in a reduction of anxiety symptoms and promotes relaxation and drowsiness.

57435-86-6

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57435-86-6 Usage

Uses

Used in Pharmaceutical Industry:
Premazepam is used as a short-term treatment for anxiety disorders and insomnia due to its ability to alleviate anxiety and induce sleep. It is prescribed for its calming effects and is typically administered in oral form, with effects lasting for several hours.
Used in Off-Label Treatments:
Although not its primary indication, Premazepam is also used off-label for conditions such as alcohol withdrawal and muscle spasms, leveraging its sedative and muscle-relaxant properties to manage symptoms associated with these conditions.
It is crucial to note that prolonged use of Premazepam can result in tolerance, dependence, and withdrawal symptoms, and carries a risk of abuse and addiction. Therefore, it should be used only as directed by a healthcare professional, and patients should be made aware of its potential for misuse.

Check Digit Verification of cas no

The CAS Registry Mumber 57435-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,4,3 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57435-86:
(7*5)+(6*7)+(5*4)+(4*3)+(3*5)+(2*8)+(1*6)=146
146 % 10 = 6
So 57435-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H15N3O/c1-10-14-12(9-18(10)2)17-13(19)8-16-15(14)11-6-4-3-5-7-11/h3-7,9H,8H2,1-2H3,(H,17,19)

57435-86-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,7-dimethyl-5-phenyl-1,3-dihydropyrrolo[3,4-e][1,4]diazepin-2-one

1.2 Other means of identification

Product number -
Other names Premazepam

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57435-86-6 SDS

57435-86-6Synthetic route

Premazepam
57435-86-6

Premazepam

8-bromo-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

8-bromo-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

Conditions
ConditionsYield
With bromine; sodium hydrogencarbonate In methanol
Premazepam
57435-86-6

Premazepam

8-chloro-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

8-chloro-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

Conditions
ConditionsYield
With sulfuryl dichloride; sodium hydrogencarbonate In dichloromethane
Premazepam
57435-86-6

Premazepam

3,7-dihydro-6,7-dimethyl-8-nitro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

3,7-dihydro-6,7-dimethyl-8-nitro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; nitric acid In dichloromethane

57435-86-6Upstream product

57435-86-6Relevant academic research and scientific papers

Pharmacologically active pyrrolodiazepines

-

, (2008/06/13)

Compounds of the following formula STR1 wherein R is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R1 is hydrogen, methyl, ethyl or phenyl; R2 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R3 is hydrogen, methoxy, trifluoromethyl, chloro, bromo or fluoro; and R4 is methyl. The new compounds are useful as CNS depressants, anticonvulsants, anti-inflammatories and inhibitors of the enzymes which promote the synthesis of prostaglandins.

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