57438-79-6Relevant academic research and scientific papers
Visible-Light-Mediated Dual Decarboxylative Coupling of Redox-Active Esters with α,β-Unsaturated Carboxylic Acids
Zhang, Jin-Jiang,Yang, Jun-Cheng,Guo, Li-Na,Duan, Xin-Hua
, p. 10259 - 10263 (2017)
An efficient visible-light-induced decarboxylative coupling between α,β-unsaturated carboxylic acids and alkyl N-hydroxyphthalimide esters has been developed. A wide range of redox-active esters derived from aliphatic carboxylic acids (1°, 2° and 3°) proved viable in this dual decarboxylation process, affording a broad scope of substituted alkenes in moderate to excellent yields with good E/Z selectivities. This redox-neutral procedure was highlighted by its mild conditions, operational simplicity, easy accessibility of carboxylic acids, and excellent functional-group tolerance.
Preparation method of internal olefin
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Paragraph 0029-0037; 0038; 0039; 0040-0043; 0054, (2020/09/16)
The invention discloses a preparation method of internal olefin. The method comprises the following steps: by taking a cinnamic acid compound and a 4-alkyl-1,4-dihydropyridine compound as raw materials, carrying out an oxidative decarboxylation alkylation reaction in the presence of a copper catalyst and dicumyl peroxide (DCP) to construct a C (sp3)-C (sp2) bond, and preparing a series of internalolefins under mild conditions. The method has a wide substrate range and excellent functional group tolerance, uses cheap and stable cinnamic acid compounds to replace aryl halides, alkenyl halides and nitroolefin, and has the advantages of low price, wide raw material sources, mild reaction conditions, simple operation and huge application potential.
Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors
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Page/Page column 89; 110, (2010/11/28)
The present invention provides imidazole derivatives of Formula (I-IV), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I-IV), and their use in treating human or animal disorders. The compounds of the inventi
