5744-68-3

Usage

Uses

Used in Pharmaceutical Research and Development:
5-BROMO-3-METHYL-1H-PYRAZOLE is used as a key building block for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of diverse molecules with potential therapeutic applications.
Used in Agrochemicals:
In the agrochemical industry, 5-BROMO-3-METHYL-1H-PYRAZOLE serves as a crucial component in the synthesis of compounds with pesticidal properties, helping to develop new and effective solutions for crop protection.
Used in Materials Science:
5-BROMO-3-METHYL-1H-PYRAZOLE is utilized in the development of new materials with specific properties, such as those with enhanced stability or reactivity, by incorporating its unique structure into the material's composition.
Used in Drug Discovery:
5-BROMO-3-METHYL-1H-PYRAZOLE is employed as a versatile building block in the construction of chemical libraries, which are essential for high-throughput screening in drug discovery. This allows researchers to identify potential lead compounds for further development into new medications.
Used in Organic Synthesis:
As a brominated pyrazole derivative, 5-BROMO-3-METHYL-1H-PYRAZOLE is used in various organic synthesis processes, enabling the creation of a wide range of chemical compounds for different applications across various industries.

Upstream product

• 31230-17-8 3-methyl-5-aminopyrazole 
• 31230-17-8 3-amino-5-methylpyrazole 

Downstream Products

• 41327-15-5 5-bromo-3-methyl-1-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Method for synthesizing chlorantraniliprole

A solvent containing 2 - amino -3 - methylbenzoic acid is stirred, N - methyl -3 - methyl -2 - amino - benzamide is dissolved in alkali liquor in a stirring reaction process, and reacted with NCS to obtain N - methyl -3 - methyl -2 - amino -5 - chloro - benzamide. The reaction of the bromination reaction, the oxidation reaction and the condensation reaction is carried out by cooperation of a catalyst so as to obtain chlorantraniliprole. By optimizing the preparation steps of chlorantraniliprole, the whole process is relatively simple in process steps, the post-treatment is simple, intermediate products can be obtained directly after the single step is finished, high environmental control requirements are not needed in the whole synthesis step, and industrialization can be conveniently realized.

Modulators of STING (Stimulator of Interferon Genes)

Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS

A method is disclosed for preparing pyrazole derivative 3-bromo- 5-methyl- 1-H- pyrazole- N-2-chloropyridine (compound of Formula I) by reacting of a compound of Formula II with halogen substituted pyridine optionally in the presence of base and organic solvent or by decarboxylation of pyrazole carboxylic acid of Formula XI in the presence of acid. In addition, provided a method of preparation of synthetic precursors of Formula II, Formula IV, Formula V, Formula VI, Formula XI, and a method of preparing a compound of Formula VII comprising reacting a compound of Formula I with an oxidant optionally in the presence of a catalyst. Also disclosed a compound of Formula I as useful synthetic precursor for preparation of anthranilamide of Formula VIII.