5744-68-3

Basic information

• Product Name: 5-BROMO-3-METHYL-1H-PYRAZOLE
• Synonyms: 5-BROMO-3-METHYL-1H-PYRAZOLE;5-Bromo-3-Methyl-1H-Pyrazole(WX637077)
• CAS NO: 5744-68-3
• Molecular Formula: C₄H₅BrN₂
• Molecular Weight: 160.9999
• Mol File: 5744-68-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-BROMO-3-METHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-METHYL-1H-PYRAZOLE(5744-68-3)
• EPA Substance Registry System: 5-BROMO-3-METHYL-1H-PYRAZOLE(5744-68-3)

Safety Data

• Hazardous Substances Data: 5744-68-3(Hazardous Substances Data)

Usage

General Description

5-BROMO-3-METHYL-1H-PYRAZOLE is a chemical compound with the molecular formula C4H5BrN2. It is a brominated pyrazole derivative, with a bromine atom attached to the 5th position of the pyrazole ring and a methyl group at the 3rd position. 5-BROMO-3-METHYL-1H-PYRAZOLE is known for its versatile applications in organic synthesis and pharmaceutical research. It is used as a building block in the synthesis of various biologically active compounds, including pharmaceuticals, agrochemicals, and materials. Additionally, 5-BROMO-3-METHYL-1H-PYRAZOLE serves as a versatile building block in the development of chemical libraries for drug discovery and development. It is available commercially in the form of a white to off-white crystalline powder.

Upstream product

• 31230-17-8 3-methyl-5-aminopyrazole 
• 31230-17-8 3-amino-5-methylpyrazole 

Downstream Products

• 41327-15-5 5-bromo-3-methyl-1-phenyl-1H-pyrazole 

Relevant articles and documents

Method for synthesizing chlorantraniliprole

A solvent containing 2 - amino -3 - methylbenzoic acid is stirred, N - methyl -3 - methyl -2 - amino - benzamide is dissolved in alkali liquor in a stirring reaction process, and reacted with NCS to obtain N - methyl -3 - methyl -2 - amino -5 - chloro - benzamide. The reaction of the bromination reaction, the oxidation reaction and the condensation reaction is carried out by cooperation of a catalyst so as to obtain chlorantraniliprole. By optimizing the preparation steps of chlorantraniliprole, the whole process is relatively simple in process steps, the post-treatment is simple, intermediate products can be obtained directly after the single step is finished, high environmental control requirements are not needed in the whole synthesis step, and industrialization can be conveniently realized.

PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS

A method is disclosed for preparing pyrazole derivative 3-bromo- 5-methyl- 1-H- pyrazole- N-2-chloropyridine (compound of Formula I) by reacting of a compound of Formula II with halogen substituted pyridine optionally in the presence of base and organic solvent or by decarboxylation of pyrazole carboxylic acid of Formula XI in the presence of acid. In addition, provided a method of preparation of synthetic precursors of Formula II, Formula IV, Formula V, Formula VI, Formula XI, and a method of preparing a compound of Formula VII comprising reacting a compound of Formula I with an oxidant optionally in the presence of a catalyst. Also disclosed a compound of Formula I as useful synthetic precursor for preparation of anthranilamide of Formula VIII.