57440-25-2

Upstream product

• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 90776-75-3 Trifluoro-methanesulfonate3,5,5-trimethyl-2-phenyl-4,5-dihydro-oxazol-3-ium; 
• 33561-48-7 5,5-dimethyl-2-phenyl-4,5-dihydrooxazole 
• 90776-82-2 (E)-2-Cyano-3-[(2-hydroxy-2-methyl-propyl)-methyl-amino]-3-phenyl-acrylic acid ethyl ester 
• 996-82-7 sodium diethylmalonate 

Relevant academic research and scientific papers

CONDENSATION DU CYANOACETATE D'ETHYLE SODE SUR LES SELS D'IMINOETHERS CYCLIQUES. SYNTHESE DIRECTE DE DERIVES D'OXAZEPINE-1,4 ONE-7

Sodium ethylcyanoacetate was found to react exclusively at the 2-position of trifluormethanesulfonate 2-alkyl(aryl) 1,3-oxazolinium salts 2.In most cases, the reaction leads specifically to a new series of 5-alkyl(aryl) 6-cyano 2,3-dihydro 1,4-oxazepine 7-ones 3.This efficient one-step ring-enlargement process occurs at the oxazolidin stage.Structural parameters affecting the scope and limitations of this condensation are discussed.