57440-68-3Relevant articles and documents
Heterogeneous amine catalyst grafted on amorphous silica: An effective organocatalyst for microwave-promoted Michael reaction of 1,3-dicarbonyl compounds in water
Hagiwara, Hisahiro,Inotsume, Sachiyo,Fukushima, Masakazu,Hoshi, Takashi,Suzuki, Toshio
, p. 926 - 927 (2006)
Michael addition of a 1,3-dicarbonyl compound to an α,β- unsaturated carbonyl compound was effectively catalyzed by heterogeneous N,N-diethylaminopropylated silica gel (NDEAP) in water under microwave heating. The reaction condition was mild, practical, a
Total Synthesis of Anti-Cancer Meroterpenoids Dysideanone B and Dysiherbol A and Structural Reassignment of Dysiherbol A
Chong, Chuanke,Zhang, Qunlong,Ke, Jia,Zhang, Haiming,Yang, Xudong,Wang, Bingjian,Ding, Wei,Lu, Zhaoyong
supporting information, p. 13807 - 13813 (2021/05/17)
The first total synthesis of marine anti-cancer meroterpenoids dysideanone B and dysiherbol A have been accomplished in a divergent way. The synthetic route features: 1) a site and stereoselective α-position alkylation of a Wieland–Miescher ketone derivative with a bulky benzyl bromide to join the terpene and aromatic moieties together and set the stage for subsequent cyclization reactions; 2) an intramolecular radical cyclization to construct the 6/6/6/6-tetracycle of dysideanone B and an intramolecular Heck reaction to forge the 6/6/5/6-fused core structure of dysiherbol A. A late-stage introduction of the ethoxy group in dysideanone B reveals that this group might come from the solvent ethanol. The structure of dysiherbol A has been revised based on our chemical total synthesis.
Studies towards the Total Synthesis of Kadcotrione B
Gangababu, Marri,Manimala, Patel,Rammohan, Aluru,Reddy, Julakanti Satyanarayana,Yadav, Jillu Singh
supporting information, p. 735 - 743 (2020/02/25)
A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are
TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS
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Page/Page column 49-50, (2019/06/11)
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.
