57461-43-5

Basic information

• Product Name: (3S)-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-2-one
• Synonyms: (3S)-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-2-one
• CAS NO: 57461-43-5
• Molecular Weight: 239.277
• Mol File: 57461-43-5.mol

Chemical Properties

• CAS DataBase Reference: (3S)-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-2-one(57461-43-5)
• EPA Substance Registry System: (3S)-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-2-one(57461-43-5)

Safety Data

• Hazardous Substances Data: 57461-43-5(Hazardous Substances Data)

Upstream product

• 1194480-64-2 N-(3-nitropyrid-2-yl)-L-phenylalanine benzyl ester 
• 1194480-63-1 N-(3-nitropyrid-2-yl)-L-phenylalanine ethyl ester 

Relevant articles and documents

Synthesis of 1,2,3,4-tetrahydropyrido- [2,3-b]pyrazine-2,3-dione derivatives with a chiral substituent at the nitrogen atom

The sequence of steps including nucleophilic substitution of the chlorine atom in 2-chloro-3-nitropyridine by esters of optically active phenylalanine, reduction of the nitro group, acylation with ethyl oxalyl chloride, and intramolecular cyclization, leads to the synthesis of derivatives of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-2,3-dione with a chiral substituent at the nitrogen atom. It was established that, depending on the conditions of carrying out the cyclization, the parallel formation of derivatives of imidazo[4,5-b]pyridine is possible. Conditions were found for selectively carrying out the cyclization under with only structures of pyrazines or imidazole condensed with pyridine were formed.