574745-75-8

Basic information

• Product Name: 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE
• Synonyms: 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE;Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(phenylmethoxy)-;4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-phenylmethoxyquinazoline;4-[(4-fluoro-2-methyl-1H-indol-5-yloxy)]-6-methoxy-7-(benzyloxy)-quinazoline
• CAS NO: 574745-75-8
• Molecular Formula: C₂₅H₂₀FN₃O₃
• Molecular Weight: 429
• Mol File: 574745-75-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 610.055 °C at 760 mmHg
• Flash Point: 322.75 °C
• Appearance: /
• Density: 1.333 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE(574745-75-8)
• EPA Substance Registry System: 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE(574745-75-8)

Safety Data

• Hazardous Substances Data: 574745-75-8(Hazardous Substances Data)

Usage

General Description

7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazoline is a chemical compound that belongs to the quinazoline family. It is a synthetic organic molecule with a complex structure, consisting of a benzyl ether group, a fluoro-substituted indole moiety, and a methoxyquinazoline scaffold. 7-(BENZYLOXY)-4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINAZOLINE may have potential pharmaceutical applications due to its unique structure and properties, such as its potential as a kinase inhibitor. Further research and studies are needed to explore the potential biological activities and therapeutic benefits of this compound.

Upstream product

• 288385-88-6 4-fluoro-2-methyl-1H-indol-5-ol 
• 162364-72-9 7-benzyloxy-4-chloro-6-methoxyquinazoline 

Downstream Products

• 574745-76-9 7-hydroxy-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazoline 
• 857036-77-2 cediranib maleate 
• 288383-20-0 cediranib 

Relevant articles and documents

Angiogenesis inhibitor as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and discloses a compound shown as a formula I or pharmaceutically acceptable salt, prodrug, metabolite, isotope derivative and solvate thereof. The compound provided by the invention is a cyclobutyl-containing compound used as a tyrosine kinase inhibitor, and can be used for treating tyrosine kinase, especially tumor diseases related to VEGFR. Due to the existence of the cyclobutyl group, the rigidity of a branched chain molecule can be improved, the directivity of the molecule is improved, the compound can be better combined with a target easily, the dosage of a drug can be reduced, and the side effect of the drug is reduced. The invention also provides a preparation method of the compound and application of the compound in treatment of tumor diseases caused by abnormal activity of tyrosine kinase such as VEGFR.

THERAPEUTIC COMPOUNDS AND USES THEREOF

Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases are also provided.

CHEMICAL PROCESS

The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline.