57479-01-3Relevant academic research and scientific papers
α,α-Dioxoketene Dithioacetals as Starting Materials for the Synthesis of Polysubstituted Pyridines
Abu-Shanab, Fathi A.,Elnagdi, Mohamed H.,Ali, Fawzy M.,Wakefield, Basil J.
, p. 1449 - 1452 (2007/10/02)
Reactions of 3-acetyl-4,4-bis(methylthio)but-3-en-2-one 2e and methyl 2-acetyl-3,3-bis(methylthio)prop-2-enoate 2f with cyanothioacetamide, cyanoacetamide, or 2-amino-1,3,3-tricyanoprop-1-ene and base, followed by treatment with acid give polysubstituted pyridines such as 8, 10, 11, 13, 15 and 16.Further elaboration of these products leads to bicyclic systems such as thienopyridines 17 and 18 and pyrazolopyridine 21 and then to tricyclic systems including pyrazolothienopyridine 19 and dipyrazolopyridine 22.
