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57479-70-6

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57479-70-6 Usage

Uses

4-Chloro-2-methoxybenzoic acid was used in the synthesis of (2-(4-chloro-2-methoxybenzoyl)-1′H-1,3′-bipyrrol-2′-yl)(2-methoxyphenyl)methanone.

General Description

4-Chloro-2-methoxybenzoic acid anion forms complexes with Mn2+, Co2+, Ni2+, Cu2+ and Zn2+.

Check Digit Verification of cas no

The CAS Registry Mumber 57479-70-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,4,7 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 57479-70:
(7*5)+(6*7)+(5*4)+(4*7)+(3*9)+(2*7)+(1*0)=166
166 % 10 = 6
So 57479-70-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)/p-1

57479-70-6 Well-known Company Product Price

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  • Alfa Aesar

  • (B21332)  4-Chloro-2-methoxybenzoic acid, 99%   

  • 57479-70-6

  • 5g

  • 524.0CNY

  • Detail
  • Alfa Aesar

  • (B21332)  4-Chloro-2-methoxybenzoic acid, 99%   

  • 57479-70-6

  • 25g

  • 1994.0CNY

  • Detail

57479-70-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-2-methoxybenzoic acid

1.2 Other means of identification

Product number -
Other names 4-Chloro-o-anisic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57479-70-6 SDS

57479-70-6Relevant articles and documents

Design, synthesis, and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

Deng, Xiangping,Liu, Renbo,Li, Junjian,Li, Zhongli,Liu, Juan,Xiong, Runde,Lei, Xiaoyong,Zheng, Xing,Xie, Zhizhong,Tang, Guotao

, p. 1874 - 1884 (2019/01/28)

According to the pharmacophore combination principle, a set of new 3′,4′,5′-trimethoxy flavonoid salicylate derivatives were designed, synthesized, and evaluated for biological activity. The cytotoxicity evaluation revealed that compound 10v exhibited higher potency than 5-Fu against HCT-116 cells. Preliminary biological activity studies showed that compound 10v could inhibit the colony formation and migration of HCT-116 cells. Besides, the Hoechst 33258 staining assay and flow cytometry revealed that treatment with compound 10v induced the apoptosis of HCT-116 cells in a concentration-dependent manner, while it had no effect on their cell cycle. The WB analysis suggested that HIF-1α, tubulin, HK-2, and PFK might be the potential pharmacophore targets of compound 10v. Tubulin was a potential drug target for compound 10v, which was explained by analyzing the crystal structure of compound 10v complexed with tubulin. These results indicated that compound 10v might be a promising anti-tumor agent candidate, deserving further optimization and evaluation.

Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential anti-tumor agents

Deng, Xiangping,Wang, Zhe,Liu, Juan,Xiong, Shujuan,Xiong, Runde,Cao, Xuan,Chen, Yanming,Zheng, Xing,Tang, Guotao

, p. 38171 - 38178 (2017/08/16)

A series of flavonoid salicylate derivatives containing trimethoxybenzene and a series of chrysin salicylate derivatives were synthesized for use as anti-tumor agents, and evaluated for antiproliferative activity using three human tumor cells: MCF-7 (breast carcinoma cells), HepG2 (liver carcinoma cells), MGC-803 (gastric carcinoma cells) and the mice tumor cells MFC (forestomach carcinoma cells). A substituent group of a suitable size and the trimethoxybenzene had a certain influence on the bioactivity of the flavonoid salicylate derivatives. Compound 2 and its salicylate derivatives 7a-7g containing the trimethoxybenzene exhibited more antiproliferative activity. Among them, compound 7g displayed the most potent antiproliferative activity against MGC-803 cells and MFC cells with the concentration causing 50% inhibition of cell growth (IC50) values of 11.05 ± 1.58 μM and 13.73 ± 2.04 μM, respectively. The flow cytometry results showed that compound 7g caused the cell cycle to be arrested in the G0/G1 phase and induced apoptosis of MFC cells in a dose-dependent manner. Furthermore, compound 7g showed good anti-tumor activity in vivo. These results suggested that compound 7g could be a new, potent anti-tumor candidate which should be optimized and evaluated further.

Meta-sulfonamido-benzamides

-

, (2008/06/13)

Meta-sulfonamido-benzamide derivatives of the formula: STR1 [wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group; R1 is a lower alkyl, phenyl, amino, lower alkylamino, di(lower)alkylamino, or C4 -C5 alkyleneamino group; R2 is a hydrogen or halogen atom or a lower alkyl, di(lower)alkylamino, or lower alkoxy group; R3 is a hydrogen atom or a methyl or methoxy group; R4 is a hydrogen or halogen atom; R5 is a lower alkyl, lower alkenyl, C3 -C6 cycloalkyl, benzyl, or halogenobenzyl group; and n is 1 or zero] or their acid addition salts, showing pharmacological activity such as anti-emetic or psychotropic activity, are provided via several routes.

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