57498-76-7Relevant articles and documents
Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on α-glucosidase
Zeng, Zhen,Yin, Xiaoli,Wang, Xueyuan,Yang, Wuying,Liu, Xiaoqin,Hong, Yanping
, p. 277 - 287 (2019)
Twenty maslinic acid and corosolic acid derivatives were obtained by coupling with L-amino acids at C-28 position. The α-glucosidase inhibitory activities of the present compounds were evaluated in vitro. Results reveal that some of the derivatives exhibit a better α-glucosidase inhibitory activity than that of acarbose in the test conditions of ethanol-water solution and DMSO. It is worth noting that maslinic acid and corosolic acid derivatives coupled aspartic acid (9f: IC50 = 382 μm and 10f: IC50 = 364 μm, respectively) have the best water solubility and thus presented higher inhibitory activity than that of acarbose (IC50 = 484 μm). Unfortunately, all of the derivatives possess lower inhibitory properties of α-glucosidase than those of the parent compounds in the measurement system of DMSO solution, even if the derivatives exhibit better water solubility than that of the parent compounds.
A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase
Chaturvedula, V. S. Prakash,Gao, Zhijie,Jones, Shannon H.,Feng, Xizhi,Hecht, Sidney M.,Kingston, David G. I.
, p. 899 - 901 (2004)
Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2α-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and β-sitosteryl-β-D-galactoside (5). The structure of the new compound 1 was established as 3β-acetoxy-2α -hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase β lyase activity.
Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases
Wen, Xiaoan,Xia, Jun,Cheng, Keguang,Zhang, Liying,Zhang, Pu,Liu, Jun,Zhang, Luyong,Ni, Peizhou,Sun, Hongbin
, p. 5777 - 5782 (2008/04/03)
The synthesis and biological evaluation of corosolic acid derivatives and related compounds as inhibitors of rabbit muscle glycogen phosphorylase a is described. Within this series of compounds, 8 (IC50 = 7.31 μM), 12d (IC50 = 3.26 μM), and 12e (IC50 = 5.1 μM) exhibited more potent activities than the parent compound 1 (IC50 = 20 μM). SAR of these compounds is also discussed.
